An Organoid-based Functional Precision Medicine Trial in Osteosarcoma

Part of paid clinical trials in Los Angeles, California.

Sponsor
Jonsson Comprehensive Cancer Center
Study ID
NCT06064682
Status
Recruiting
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Conditions

  • Osteosarcoma

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Not accepted

Interventions

  • standard of care biopsy — OTHER
    Image-guided or surgical biopsy of the lesion that is suspected to be osteosarcoma in a patient with localized disease (Group 1)
  • standard of care biopsy — OTHER
    Image-guided or surgical biopsy or excision of the lesion that is suspected to be recurrent or metastatic osteosarcoma (Group 2).

Study Details

The purpose of this study is to examine if we can predict sensitivity of osteosarcoma to different chemotherapy agents using tissue cultures in the laboratory. We know that different chemotherapy agents can be used in the treatment, but not every sarcoma responds to them equally. It is important to understand if testing of the tissue obtained during a routine biopsy or surgery may be useful in selecting appropriate treatments. In addition, additional testing of the tumor, including genetic testing, will help us to understand osteosarcoma better.

Key Dates

Start date
Feb 12, 2024
Status verified
May 2026
Primary completion
Jan 1, 2027
Completion
Jan 1, 2028

Study Design

Enrollment
40 participants (estimated)

Arms

  • Arm: Group 1: local tumor
    patients with localized osteosarcoma who are scheduled to undergo diagnostic biopsy and are planned for surgical excision of the primary tumor
  • Arm: Group 2: metastatic disease
    patients with metastatic osteosarcoma who are scheduled to undergo either biopsy or surgery of metastatic disease

Primary Outcome Measure

organoids from initial biopsy [ Time Frame: two years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UCLA / Jonsson Comprehensive Cancer CenterLos AngelesCalifornia90095
Summer Swearingen
[email protected]
424-766-9349

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By research site
UCLA / Jonsson Comprehensive Cancer Center· Los Angeles, CA

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