Spatial-Motor Stroke-Rehab Study

Conditions

• Spatial Neglect
• Stroke

Eligibility Criteria

Sex

ALL

Age

18 Years - 90 Years

Healthy Volunteers

Accepted

Interventions

• Prism adaptation therapy (PAT) + Electrical stimulation (E-stim) — DEVICE
  PAT requires one to wear prism lenses while making arm-reaching movements toward visual targets. For treating left-sided neglect, a person wears the prism lenses that shift the visual field, including the images of the target and of one's own reaching arm, certain degrees to the right depending on the diopter of the lens (e.g., the 20-diopter lens shifts the visual field by 11.4 degrees). The visual system adapts over the repetitive practice of the arm reaching toward the target. The person eventually achieves success with a leftward movement reaching the actual target. Electrical stimulation (E-stim) involves parameters and settings commonly used in clinical practice as well as research for pain relief and other applications, commonly referred to as transcutaneous electrical nerve stimulation (TENS). TENS and E-stim are delivered using FDA-approved, commercially available portable clinical transcutaneous electrical stimulators (e.g. Empi TENS Unit).
• Prism adaptation therapy (PAT) + Sham Stimulator — DEVICE
  Participants in the PAT with sham stim condition group will receive sham electrical stimulation treatment (electrodes will be attached but the stimulator will not be turned on) to the left upper limb with the same placement of electrodes while undergoing PAT.
• Gait Training — OTHER
  After PAT, participants will complete multiple 30-seconds to 4-minute bouts of walking on the treadmill or overground at speeds ranging from self-selected to fast speeds (faster than comfortable self-selected speed), with rest breaks between bouts.

Study Details

The purpose of this study is to understand how prism adaptation training with and without electrical stimulation changes visuospatial behavior, motor system neurophysiology, and walking dysfunction.

Key Dates

Start date

Apr 11, 2023

Status verified

May 2026

Primary completion

Sep 30, 2026

Completion

Sep 30, 2026

Study Design

Enrollment

65 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

OTHER

Arms

• Active Comparator: Young Able-Bodied individuals
  18-30 years old able-bodied individuals (healthy without any physical disability or neurological disorder).
• Active Comparator: Old Able-Bodied individuals
  45-90 years old able-bodied individuals (healthy without any physical disability or neurological disorder).
• Experimental: Stroke with Spatial Neglect (SN) individuals
  40-90 years individuals with more than 3 months following right hemisphere stroke.

Primary Outcome Measure

Change in visuospatial pointing behavior [ Time Frame: Pre-training and immediately after training session ]

Central Contacts

• Fisayo Aloba, PT, DPT
  404-712-5803
  [email protected]

Locations (3)

Find similar trials in Atlanta, GA

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