Effect of Percussive Massage on Skeletal Muscle During Limb Immobilization

Part of paid clinical trials in Provo, Utah.

Sponsor
Brigham Young University
Study ID
NCT06053229
Status
Recruiting
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Conditions

  • Massage Therapy
  • Muscular Atrophy

Eligibility Criteria

Sex
ALL
Age
18 Years - 50 Years
Healthy Volunteers
Accepted

Interventions

  • percussive massage — DEVICE
    30 minutes of percussive massage will be administered twice per day during the 10 day immobilization period using a percussive massage device
  • Leg Immobilization — COMBINATION_PRODUCT
    All subjects will have their left leg immobilized using an immobilization brace for 10 days

Study Details

The primary aims of this study are to determine the effect of percussive massage (30 min/session, 2 sessions/day, daily) during 10 days of unilateral limb immobilization on preserving muscle, vascular, and mitochondrial function. The following hypotheses will be tested: Hypothesis 1: Percussive massage will attenuate the loss of size, strength and endurance over the immobilization period compared to the control group, as measured by MRI, maximal isometric and isokinetic force production and muscle endurance test using Biodex dynamometry. Hypothesis 2: Percussive massage will attenuate the loss of vascular function and blood flow compared to the control group as measured by passive leg movement and femoral artery blood flow. Hypothesis 3: Percussive massage will attenuate the loss of skeletal muscle mitochondrial function and decrease H2O2 production during immobilization compared to the control group, as measured by high-resolution respirometry.

Key Dates

Start date
Mar 1, 2023
Status verified
Aug 2024
Primary completion
Dec 31, 2024
Completion
Jul 31, 2025

Study Design

Enrollment
36 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Massage
    Subjects will receive a daily 30 minute percussive massage treatment on the knee extensor muscles twice per day during the 10 day immobilization period
  • Sham Comparator: Control
    This group will lie on the bed for a total of 30 minutes, but receive no massage

Primary Outcome Measure

knee extensor muscle strength [ Time Frame: Immediately before the onset of leg immobilization and after 10 days of leg immobilization ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Brigham Young UniversityProvoUtah84602
Robert D Hyldahl, PhD
[email protected]
801-422-1237
Ty Hopkins, PhD
[email protected]
8014221573

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By research site
Brigham Young University· Provo, UT

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