NIV for Hypercapnic Respiratory Failure: AVAPS vs S/T BIPAP

Conditions

• Hypercapnic Respiratory Failure

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Average Volume-Assured Pressure Support (AVAPS) — DEVICE
  A setting on noninvasive ventilator that allows setting of maximum and minimum inspiratory pressure and sets a target tidal volume. The inspiratory pressure varies breath to breath to ensure pre-set tidal volume is delivered.
• Bilevel Positive Airway Pressure Spontaneous Timed (BIPAP S/T) — DEVICE
  A setting on noninvasive ventilator that allows setting of inspiratory pressure, inspiratory time, expiratory pressure, and backup rate to deliver variable tidal volumes.

Study Details

The goal of this study is to compare two different modes of noninvasive ventilation in hypercapnic respiratory failure. The investigators will compare AVAPS and BIPAP S/T and hypothesize that AVAPS will result in a decreased length of stay in the ICU or on telemetry. Currently, noninvasive ventilation is the standard of care for hypercapnic respiratory failure. However, the most effective mode for patients with hypercapnic respiratory failure is unclear.

Key Dates

Start date

Oct 7, 2023

Status verified

Oct 2023

Primary completion

Sep 28, 2025

Completion

Sep 1, 2026

Study Design

Enrollment

100 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Active Comparator: Average Volume-Assured Pressure Support (AVAPS)
  Average Volume-Assured Pressure Support (AVAPS) setting on the noninvasive ventilator. The exact AVAPS setting will be titrated by the clinical team involved directly in the patient's care based on patient comfort and clinical response.
• Active Comparator: Bilevel Positive Airway Pressure Spontaneous Timed (BIPAP S/T)
  Bilevel Positive Airway Pressure Spontaneous Timed (BIPAP S/T) setting on the noninvasive ventilator. The exact BIPAP S/T setting will be titrated by the clinical team involved directly in the patient's care based on patient comfort and clinical response.

Primary Outcome Measure

ICU length of stay of telemetry length of stay [ Time Frame: within one week of hospital discharge (5-7 days) ]

Central Contacts

• Sara Velichkovikj
  (212)-434-4087
  [email protected]

Locations (1)

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