A Study of Orforglipron (LY3502970) Compared With Semaglutide in Participants With Type 2 Diabetes Inadequately Controlled With Metformin

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
Eli Lilly and Company
Study ID
NCT06045221
Phase
PHASE3
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

The main purpose of this study is to assess efficacy and safety of orforglipron compared with oral semaglutide in participants with Type 2 diabetes and inadequate glycemic control with metformin.The study will last around 61 weeks.

Key Dates

Start date
Sep 22, 2023
Status verified
Sep 2025
Primary completion
Aug 22, 2025
Completion
Aug 22, 2025

Study Design

Enrollment
1,698 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Orforglipron Dose 1
    Participants will receive orforglipron orally.
  • Experimental: Orforglipron Dose 2
    Participants will receive orforglipron orally.
  • Active Comparator: Semaglutide Dose 1
    Participants will receive semaglutide orally.
  • Active Comparator: Semaglutide Dose 2
    Participants will receive semaglutide orally.

Primary Outcome Measure

Change from Baseline in Hemoglobin A1c (HbA1c) [ Time Frame: Baseline, Week 52 ]

Locations (64)

FacilityCityStateZIPSite coordinators
Absolute Clinical ResearchPhoenixArizona85051-
San Fernando Valley Health InstituteCanoga ParkCalifornia91304-
Neighborhood Healthcare Institute of HealthEscondidoCalifornia92025-
Velocity Clinical Research, GardenaGardenaCalifornia90247-
Biopharma Informatic, LLCLos AngelesCalifornia90035-
Velocity Clinical Research, WestlakeLos AngelesCalifornia90057-
Infinity Clinical Research - NorcoNorcoCalifornia92860-
Valley Clinical Trials, Inc.NorthridgeCalifornia91325-
Norcal Endocrinology & Internal MedicineSan RamonCalifornia94583-
Encompass Clinical ResearchSpring ValleyCalifornia91978-
University Clinical Investigators, Inc.TustinCalifornia92780-
New West Physicians Clinical ResearchGoldenColorado80401-
Connecticut Clinical Research - CromwellCromwellConnecticut06416-
Clinical Research of West Florida, Inc. (Clearwater)ClearwaterFlorida33765-
South Florida Clinical Research InstituteMargateFlorida33063-
Miami Dade Medical Research Institute, LLCMiamiFlorida33176-
West Orange EndocrinologyOcoeeFlorida34761-
Latin Clinical Trial Center FloridaTamaracFlorida33321-
Clinical Research of West FloridaTampaFlorida33606-
Metabolic Research Institute, Inc.West Palm BeachFlorida33401-
Balanced Life Health Care Solutions/SKYCRNGLawrencevilleGeorgia30046-
Clinical Research AtlantaStockbridgeGeorgia30281-
North Georgia Clinical ResearchWoodstockGeorgia30189-
Northwest Clinical TrialsBoiseIdaho83704-
Family First Medical CenterIdaho FallsIdaho83404-
American Health Network of Indiana, LLC - GreenfieldGreenfieldIndiana46140-
Velocity Clinical Research, ValparaisoValparaisoIndiana46383-
Cotton O'Neil Diabetes & EndocrinologyTopekaKansas66606-
Tekton Research, IncWichitaKansas67218-
DelRicht ResearchNew OrleansLouisiana70115-
Joslin Diabetes CenterBostonMassachusetts02215-
Revival Research Institute, LLCDearbornMichigan48126-
SKY Integrative Medical Center/SKYCRNGRidgelandMississippi39157-
Kansas City Research InstituteKansas CityMissouri64131-
Logan Health ResearchKalispellMontana59901-
Wr-Crcn, LlcLas VegasNevada89106-
Premier ResearchTrentonNew Jersey08611-
Albany Medical College, Division of Community EndocrinologyAlbanyNew York12203-
Ellipsis Research Group - Brooklyn - 7th StreetBrooklynNew York11215-
Great Lakes Medical Research, LLCWestfieldNew York14787-
PharmQuest Life Sciences, LLCGreensboroNorth Carolina27408-
Lucas Research, IncMorehead CityNorth Carolina28557-
Accellacare - PiedmontStatesvilleNorth Carolina28625-
Wake Forest University Baptist Medical Center (WFUBMC)Winston-SalemNorth Carolina27104-
Aventiv Research IncColumbusOhio43213-
Tekton Research, IncMooreOklahoma73160-
Alliance for Multispecialty Research, LLCNormanOklahoma73069-
The Corvallis Clinic, P.C.CorvallisOregon97330-
Heritage Valley Medical Group, Inc.BeaverPennsylvania15009-
Preferred Primary Care Physicians, Preferred Clinical Research (Ofc 18)PittsburghPennsylvania15236-
The Research Center of The UpstateGreenvilleSouth Carolina29607-
New Phase Research and DevelopmentKnoxvilleTennessee37909-
Clinical Neuroscience Solutions Inc.MemphisTennessee38119-
Velocity Clinical Research, AustinAustinTexas78759-
Velocity Clinical Research, DallasDallasTexas75230-
Diabetes and Thyroid Center of Ft. WorthFort WorthTexas76132-
Clear Brook Medical AssociatesHoustonTexas77089-
Endocrine Ips, PllcHoustonTexas77079-
Juno ResearchHoustonTexas77040-
Southern Endocrinology AssociatesMesquiteTexas75149-
Texas Valley Clinical ResearchWeslacoTexas78596-
Synexus Clinical Research US, Inc.Salt Lake CityUtah84106-
Eastside Research AssociatesRedmondWashington98052-
Rainier Clinical Research CenterRentonWashington98057-

Related coverage on Hipa.ai

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By research site
Absolute Clinical Research· Phoenix, AZSan Fernando Valley Health Institute· Canoga Park, CANeighborhood Healthcare Institute of Health· Escondido, CAVelocity Clinical Research, Gardena· Gardena, CABiopharma Informatic, LLC· Los Angeles, CAVelocity Clinical Research, Westlake· Los Angeles, CA

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