tACS for Neuropathic Pain Management After SCI

Conditions

• Neuropathic Pain Management

Eligibility Criteria

Sex

ALL

Age

18 Years - 75 Years

Healthy Volunteers

Not accepted

Interventions

• tACS Sham — DEVICE
  Sham tACS will applied to the brain through the scalp for 20 minutes.
• tACS 10Hz — DEVICE
  10Hz tACS will applied to the brain through the scalp for 20 minutes.
• tACS 20Hz — DEVICE
  20Hz tACS will applied to the brain through the scalp for 20 minutes.

Study Details

The overall goal is to investigate the effectiveness of a novel intervention - transcranial alternating current stimulation (tACS) for neuropathic pain management in people after spinal cord injury.

Key Dates

Start date

Sep 1, 2025

Status verified

May 2026

Primary completion

Sep 30, 2027

Completion

Mar 31, 2028

Study Design

Enrollment

14 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Arms

• Experimental: "tACS Sham, tACS 10Hz, tACS 20Hz" experimental order
  1. tACS Sham is a temporary non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for up to 30 second, it is not designed to entrain neuronal activity into any external regulatory frequency patterns. 2. tACS 10Hz is a 10Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp or 20 or 40 minutes to entrain neuronal activity into 10Hz frequency patterns. 3. tACS 20Hz is a 20Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for 20 or 40 minutes to entrain neuronal activity into 20Hz frequency patterns.
• Experimental: "HD-tACS 20Hz, HD-tACS 10Hz, HD-tACS Sham" experimental order
  1. tACS 20Hz is a 20Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for 20 or 40 minutes to entrain neuronal activity into 20Hz frequency patterns. 2. tACS 10Hz is a 10Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp or 20 or 40 minutes to entrain neuronal activity into 10Hz frequency patterns. 3. tACS Sham is a temporary non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for up to 30 second, it is not designed to entrain neuronal activity into any external regulatory frequency patterns.
• Experimental: "HD-tACS 10Hz, HD-tACS 20Hz, HD-tACS Sham" experimental order
  1. tACS 10Hz is a 10Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp or 20 or 40 minutes to entrain neuronal activity into 10Hz frequency patterns. 2. tACS 20Hz is a 20Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for 20 or 40 minutes to entrain neuronal activity into 20Hz frequency patterns. 3. tACS Sham is a temporary non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for up to 30 second, it is not designed to entrain neuronal activity into any external regulatory frequency patterns.

Primary Outcome Measure

Pain scale (visual analogue scale, VAS) measurement [ Time Frame: Change of VAS 5 minutes before and after the tACS intervention will be measured. ]

Central Contacts

• Sheng Li, MD, Ph.D
  (713) 797-7125
  [email protected]
• Shengai Li, MS
  713-797-7561
  [email protected]

Locations (1)

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