Blood Flow Regulation and Neuromuscular Function Post-Stroke

Part of paid clinical trials in Milwaukee, Wisconsin.

Sponsor
Medical College of Wisconsin
Study ID
NCT06027294
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • Ischemic Conditioning — PROCEDURE
    A cuff will be inflated to a pressure of 225 mmHg.

Study Details

The muscles of stroke survivors can fatigue faster compared to muscles in people who have not had a stroke, which can limit how long a person with stroke can perform tasks such as walking. This study will examine how blood flow is regulated to the exercising leg muscle post-stroke, because if the muscle does not receive enough blood flow it will become fatigued. Finally, the investigators will use a safe and simple non-invasive intervention called ischemic conditioning, which has known effects to improve blood flow to exercising muscle and determine the effects on muscle fatigue.

Key Dates

Start date
Jan 11, 2024
Status verified
Sep 2025
Primary completion
Jun 30, 2028
Completion
Jun 30, 2028

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Ischemic Conditioning
    Ischemic conditioning is a well-defined, non-invasive procedure which consists of inflating a blood pressure cuff around a limb (in our study, the paretic leg), inflating the cuff to 225 mmHg to occlude blood flow to the limb for 5 minutes, releasing the cuff for 5 minutes, and repeating 5 times. In our study, participants will receive six sessions of ischemic conditioning over the course of two weeks.
  • Sham Comparator: Ischemic Conditioning Sham
    There will also be an IC Sham group which is identical to the IC intervention, except the cuff will only be inflated to 10 mmHg, which is not a high enough pressure to occlude arterial blood flow.

Primary Outcome Measure

Functional Sympatholysis Magnitude [ Time Frame: Years 3-5 ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Marquette UniversityMilwaukeeWisconsin53233
Allison S. Hyngstrom, PT, PhD
[email protected]
414-288-4566
Medical College of WisconsinMilwaukeeWisconsin53226
Matthew J Durand, Ph.D.
[email protected]
414-955-5619

Find similar trials in Milwaukee, WI

By condition
Stroke
By specialty
NeurologyBrain disorders
By research site
Marquette University· Milwaukee, WIMedical College of Wisconsin· Milwaukee, WI

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