Single-tracer Multiparametric PET Imaging

Part of paid clinical trials in Sacramento, California.

Sponsor
University of California, Davis
Study ID
NCT06014515
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Cardiovascular Disease
  • Healthy Subjects

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • 18F-FDG — DRUG
    Each subject will undergo a dynamic 18F-FDG PET/CT scan (this drug is FDA approved) and a dynamic 11C-butanol PET/CT scan (this drug is under an IND) on the EXPLORER total-body PET/CT system. The two scans will be performed on the same day or within a period of up to two weeks depending on subject, imaging agent and scanner availability.
  • 11C-butanol — DRUG
    Each subject will undergo a dynamic 18F-FDG PET/CT scan (this drug is FDA approved) and a dynamic 11C-butanol PET/CT scan (this drug is under an IND) on the EXPLORER total-body PET/CT system. The two scans will be performed on the same day or within a period of up to two weeks depending on subject, imaging agent and scanner availability.

Study Details

The overarching goal of this project is to develop and evaluate a single-tracer multiparametric positron emission tomography (PET) imaging solution for simultaneous imaging of blood flow and glucose metabolism using 18F-fluorodeoxyglucose (FDG) alone. The investigators working hypothesis is that quantitative blood flow can be extracted from dynamic 18F-FDG PET data by use of tracer kinetic modeling, in addition to glucose metabolism that 18F-FDG is conventionally used for.

Key Dates

Start date
Feb 14, 2024
Status verified
Jul 2025
Primary completion
Aug 31, 2028
Completion
Aug 31, 2033

Study Design

Enrollment
60 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Experimental: PET/CT scans
    Each subject will undergo a dynamic 18F-FDG PET/CT scan and a dynamic 11C-butanol PET/CT scan on the EXPLORER total-body PET/CT system

Primary Outcome Measure

Blood Flow [ Time Frame: during the procedure ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UC Davis EXPLORER Molecular Imaging CenterSacramentoCalifornia95816
Dana Little, MS
[email protected]
916-734-7749
Guobao Wang, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
UC Davis EXPLORER Molecular Imaging Center· Sacramento, CA

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