A Study of Post COVID-19 Mechanisms for Chronic Lung Sequelae

Part of paid clinical trials in Rochester, Minnesota.

Sponsor
Mayo Clinic
Study ID
NCT06006884
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Bronchoscopies and Bronchoalveolar Lavages (BALs) — PROCEDURE
    Bronchoscopies use a thin, lighted tube, which enters through the mouth or nose and moves down the throat to the airways to look at the lungs. BALs are done during bronchoscopies to collect samples from the lungs for testing. During this procedure, a saline solution is put through the tube to wash the airways and collect a fluid sample.
  • Chest Tomography (CT) — DIAGNOSTIC_TEST
    X-ray to create images of the bones and internal organs of the body
  • Electrocardiogram (ECG) — DIAGNOSTIC_TEST
    Measures the electrical activity of the heart by using sticky pads that are placed on your chest and limbs.
  • Pulmonary function tests (PFTs) — DIAGNOSTIC_TEST
    Testing to measure how well lungs are working
  • 6 minute walk test (6MWT) — DIAGNOSTIC_TEST
    Walking test to see how well the lungs function with exercise over 6 minutes

Study Details

The purpose of this study is to understand why some people experience long term effects, such as shortness of breath and fatigue, after a severe COVID-19 infection

Key Dates

Start date
Jan 10, 2024
Status verified
Apr 2026
Primary completion
Aug 31, 2027
Completion
Aug 31, 2027

Study Design

Enrollment
67 participants (estimated)

Arms

  • Arm: Sequelae group
    COVID-19 convalescents that recover from prior severe acute diseases requiring hospitalization and who will be at high risk of chronic lung sequelae (with an estimate of \>50% having moderate to severe sequelae based on current literature)
  • Arm: Recovery group
    Age and gender matched individuals who had mild SARS-CoV-2 infection and experienced complete resolution of symptoms

Primary Outcome Measure

Decipher clinical, imaging, immune, molecular and/or viral traits underlying post-acute COVID-19 lung sequelae [ Time Frame: 4 years ]

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo Clinic MinnesotaRochesterMinnesota55905
Chris Roberts
[email protected]
800-753-1606

Find similar trials in Rochester, MN

By condition
COVID-19 / long COVID
By specialty
Infectious disease
By research site
Mayo Clinic Minnesota· Rochester, MN

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