Accelerated Transcranial Magnetic Stimulation for People With Schizophrenia Treated With Clozapine

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
Deepak K. Sarpal, M.D.
Study ID
NCT06003036
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 50 Years
Healthy Volunteers
Not accepted

Interventions

  • sham stimulation — DEVICE
    sham delivery of transcranial magnetic stimulation
  • transcranial magnetic stimulation — DEVICE
    accelerated intermittent theta burst stimulation

Study Details

In this study, the investigators will examine whether a type of repetitive transcranial magnetic stimulation called accelerated intermittent theta burst stimulation (iTBS) can augment neurocognition in individuals who receive treatment with clozapine. Following a baseline evaluation and magnetic resonance imaging (MRI), participants will undergo a session of iTBS +MRI and session of sham delivery + MRI. The order for these sessions will be blinded and randomized. The investigators predict that accelerated iTBS will enhance neurocognition relative to sham delivery.

Key Dates

Start date
Dec 1, 2023
Status verified
Apr 2026
Primary completion
Feb 28, 2026
Completion
Jul 31, 2026

Study Design

Enrollment
30 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: iTBS, then Sham
  • Experimental: Sham, then iTBS

Primary Outcome Measure

change in brain functional connectivity within the prefrontal cortex [ Time Frame: 1 hour ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UPMC Western Psychiatric Hospital/University of PittsburghPittsburghPennsylvania15213
Tori Blazinski
[email protected]

Find similar trials in Pittsburgh, PA

By condition
Schizophrenia
By specialty
PsychiatryMental healthBehavioral health
By research site
UPMC Western Psychiatric Hospital/University of Pittsburgh· Pittsburgh, PA

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