Repurposing Atovaquone for the Treatment of Platinum-Resistant Ovarian Cancer

Part of paid clinical trials in Atlanta, Georgia.

Sponsor
Emory University
Study ID
NCT05998135
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

  • Ovarian High Grade Serous Adenocarcinoma
  • Platinum-Resistant Ovarian Carcinoma

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Atovaquone — DRUG
    Given PO
  • Biopsy — PROCEDURE
    Undergo biopsy
  • Computed Tomography — PROCEDURE
    Undergo CT
  • Paracentesis — PROCEDURE
    Undergo paracentesis

Study Details

This phase II trial test tests how well repurposing atovaquone works in treating patients with platinum-resistant ovarian cancer. Atovaquone is used for the treatment or prevention of certain infections. Atovaquone is in a class of medications called antiprotozoal agents. It works by stopping the growth of certain types of protozoa that can cause pneumonia. Giving atovaquone may be effective in treating platinum-resistant ovarian cancer and result in improved outcomes compared to standard chemotherapy regimens.

Key Dates

Start date
Nov 9, 2023
Status verified
Sep 2025
Primary completion
Jun 30, 2026
Completion
Jun 30, 2027

Study Design

Enrollment
28 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Treatment (atovaquone)
    Patients receive atovaquone PO on study. Patients also undergo CT and biopsy or paracentesis throughout the study.

Primary Outcome Measure

Progression free survival (PFS) [ Time Frame: From initiation of atovaquone to progression or death, assessed up to 1 year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Emory University Hospital/Winship Cancer InstituteAtlantaGeorgia30322
Nina Kimball
[email protected]
404-778-8145
Maisey S Ratcliffe
[email protected]
404-778-3449
Namita Khanna, MD, MSPH (PRINCIPAL_INVESTIGATOR)

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By research site
Emory University Hospital/Winship Cancer Institute· Atlanta, GA

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