Changes in Inhibition and Valuation After Eating

Part of paid clinical trials in New York, New York.

Sponsor
Icahn School of Medicine at Mount Sinai
Study ID
NCT05995496
Status
Recruiting
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Conditions

  • Bulimia Nervosa

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • Fasting state — OTHER
    16 hours of fasting
  • Fed state — OTHER
    Fed a standardized meal
  • Magnetic Resonance Imaging — OTHER
    Neuroimaging with computational modeling

Study Details

An impaired ability to exert control has been implicated in bulimia nervosa (BN), but this impairment may not represent a stable trait or be the most effective focus for treatment. This project aims to understand how predictions and value-based decisions about control may be abnormally influenced by eating in individuals with BN, thereby maintaining cycles of binge eating, purging, and restriction.

Key Dates

Start date
Dec 12, 2023
Status verified
Feb 2026
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
150 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER

Arms

  • Experimental: Participants with Bulimia Nervosa
    Participants are randomly assigned (in even numbers across the two groups) to scan order: A. These participants are first scanned after 16 hours of fasting on one day, and are next scanned after a standardized meal on a second day. B. These participants are first scanned after a standardized meal on one day, and are next scanned after 16 hours of fasting on a second day.
  • Active Comparator: Participants without Bulimia Nervosa
    Participants are randomly assigned (in even numbers across the two groups) to scan order: A. These participants are first scanned after 16 hours of fasting on one day, and are next scanned after a standardized meal on a second day. B. These participants are first scanned after a standardized meal on one day, and are next scanned after 16 hours of fasting on a second day.

Primary Outcome Measure

Frontostriatal Activation Associated with Prediction Errors on the Stop Signal Task [ Time Frame: 1-2.5 hours after a 16-hour fast (fasted state) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Center of Excellence in Eating and Weight Disorders at the Icahn School of Medicine at Mount SinaiNew YorkNew York10029
Jiulin Dai, B.S.
[email protected]
212-824-9561
Riley Macks
[email protected]
(212) 824-9545
Laura A Berner (PRINCIPAL_INVESTIGATOR)

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By research site
Center of Excellence in Eating and Weight Disorders at the Icahn School of Medicine at Mount Sinai· New York, NY

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