Anthocyanin-Rich Table Grape Powder for Prophylaxis of Post-Operative Atrial Fibrillation

Conditions

• Post-operative Atrial Fibrillation (POAF)

Eligibility Criteria

Sex

ALL

Age

18 Years - 79 Years

Healthy Volunteers

Not accepted

Interventions

• Freeze-Dried California Table Grape — DRUG
  Consume 2 servings (30.66g/serving) per day for three days before cardiac surgery
• Placebo — DRUG
  Consume 2 servings (30.66g/serving) per day for three days before cardiac surgery

Study Details

Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery and leads to worse outcomes. POAF is thought to be caused by the inflammatory state following cardiac surgery. It may be that anti-inflammatory medications could lower the occurrence of POAF, however many typical anti-inflammatory medications, such as ibuprofen, are contraindicated in the post cardiac surgery patient due to increased risks of bleeding. If a drug was identified with anti-inflammatory properties with minimal deleterious side effects, this could be broadly applied to cardiac surgery patients for the prevention of POAF. Interestingly, several small trials have shown that medications that alter transcription of inflammatory markers lead to decreased POAF. Furthermore, we have shown that phytochemicals, such as those found in grapes, have excellent bioavailability and can affect cardiac gene transcription related to inflammation. In this study, we propose to evaluate the efficacy of preoperative administration of concentrated grape powder in the prevention of POAF.

Key Dates

Start date

Mar 23, 2026

Status verified

Apr 2026

Primary completion

Aug 31, 2027

Completion

Aug 31, 2027

Study Design

Enrollment

70 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Arms

• Experimental: Concentrated grape powder
• Placebo Comparator: Placebo

Primary Outcome Measure

POAF-related events during initial hospital stay and within 30 days after surgery [ Time Frame: 30 days ]

Central Contacts

• China Green, BS
  734-936-7731
  [email protected]

Locations (1)

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