Breathing Rescue for SUDEP Prevention

Part of paid clinical trials in Houston, Texas.

Sponsor
The University of Texas Health Science Center, Houston
Study ID
NCT05981755
Status
Recruiting
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Conditions

  • Focal Epilepsy

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Breathing tasks — OTHER
    Breathing tasks include normal breathing through nose or mouth, breathing while resting wakefully, increase and decrease in breathing rate, and breath counting.
  • Brain mapping with stimulation — DEVICE
    Electrical stimulation will be used to find specific areas of the brain involved in breathing function. Stimulation will be applied using a Nihon Kohden MEE-1000A neural function measuring system with the MS-120BK extension unit for brain stimulation.

Study Details

The purpose of this study is to precisely delineate human brain networks that modulate respiration and identify specific brain areas and stimulation techniques that can be used to prevent seizure-induced breathing failure.

Key Dates

Start date
Jul 31, 2023
Status verified
Jun 2025
Primary completion
Jun 30, 2028
Completion
Jun 30, 2028

Study Design

Enrollment
100 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Breathing tasks and Brain mapping with stimulation

Primary Outcome Measure

Change in percentage of breathing node size as assessed by electroencephalogram (EEG) signal [ Time Frame: baseline (before breathing task), at the time of the breathing task (about 8 minutes after start of baseline) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
The University of Texas Health Science Center at HoustonHoustonTexas77030
Nuria L Lecumberri, MD,PhD
[email protected]
713-500-7785
Sandhya Rani, PhD
[email protected]
713-500-7499

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By research site
The University of Texas Health Science Center at Houston· Houston, TX

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