Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorder

Conditions

• Alcohol Use Disorder

Eligibility Criteria

Sex

ALL

Age

21 Years - 70 Years

Healthy Volunteers

Accepted

Interventions

• Detoxification Program — OTHER
  Patients will begin inpatient or outpatient detoxification prior to completing imaging
• PKAB — RADIATION
  90 PET Imaging Scan using \[11C\]LY2795050 (AKA \[11C\]PKAB)
• CFN — RADIATION
  90 Pet Imaging Scan using \[11C\]-Carfentanil

Study Details

The primary objective of this multimodal positron emission tomography (PET) study is to use PET brain imaging to measure both MOR (Mu-Opioid receptors) and KOR (kappa-opioid receptors) in participants with alcohol use disorder (AUD) and to quantify the relationships between MOR and KOR, separately and jointly, to key clinical outcomes (e.g., craving, mood, withdrawal, time to lapse) during a quit attempt.

Key Dates

Start date

Nov 7, 2023

Status verified

Mar 2025

Primary completion

Aug 1, 2028

Completion

Nov 1, 2028

Study Design

Enrollment

100 participants (estimated)

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Alcohol Use Disorder population completing Detoxification
  Subjects will be asked to complete both 90 minute \[11C\]CFN and 90 minute \[11C\]PKAB PET Imaging after 1-3 days of a detoxification program.
• Experimental: Healthy Control population
  Subjects will be asked to complete both a 90 minute \[11C\]CFN and a 90 minute \[11C\]PKAB PET Imaging.

Primary Outcome Measure

Regional binding availability and volume of distribution of (Mu-Opioid receptors) [ Time Frame: Within first 6 days of abstinence ]

Central Contacts

• Marc Grasso
  2037375083
  [email protected]
• Kelly Cosgrove, PhD
  2037376969
  [email protected]

Locations (1)

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