Endotypic Traits and Obstructive Sleep Apnea Surgery

Part of paid clinical trials in Santa Monica, California.

Sponsor
University of California, Los Angeles
Study ID
NCT05953610
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

  • Obstructive Sleep Apnea

Eligibility Criteria

Sex
ALL
Age
21 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Acetazolamide 500 MG QHS — DRUG
    Acetazolamide
  • Eszopiclone 3 mg QHS — DRUG
    Eszopiclone

Study Details

This study will examine factors associated with outcomes after soft palate surgery and medications (acetazolamide, eszopiclone) that may treat other potential causes of obstructive sleep apnea (loop gain, arousal threshold).

Key Dates

Start date
Jan 7, 2024
Status verified
Jun 2025
Primary completion
Aug 31, 2028
Completion
Aug 31, 2028

Study Design

Enrollment
150 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: Acetazolamide
    Treatment with acetazolamide 500 mg nightly for 1 month.
  • Experimental: Acetazolamide/Eszopiclone
    Treatment with acetazolamide 500 mg and eszopiclone 3 mg nightly for 1 month.

Primary Outcome Measure

Apnea-hypopnea index [ Time Frame: 6 months ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
UCLA Santa Monica Medical CenterSanta MonicaCalifornia90401
Eric Kezirian, MD, MPH
Eric Kezirian, MD, MPH (PRINCIPAL_INVESTIGATOR)
UCLA WestwoodWestwood, Los AngelesCalifornia90095
Eric Kezirian, MD, MPH
Eric Kezirian, MD, MPH (PRINCIPAL_INVESTIGATOR)

Find similar trials in Santa Monica, CA

By research site
UCLA Santa Monica Medical Center· Santa Monica, CAUCLA Westwood· Westwood, Los Angeles, CA

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