Neurophysiologic Biomarkers for Cognitive Rehabilitation

Conditions

• Schizophrenia Spectrum Disorders

Eligibility Criteria

Sex

ALL

Age

18 Years - 75 Years

Healthy Volunteers

Accepted

Interventions

• Neurophysiologic Biomarker Assessments — OTHER
  Non-invasive electroencephalography will be recorded to derive neurophysiologic biomarkers.

Study Details

Cognitive symptoms of schizophrenia interfere with daily life-from managing self-care, to more complex tasks like taking medications and living independently. Unfortunately, these cognitive symptoms are not corrected by 'standard of care' treatments (antipsychotic medications), although some schizophrenia patients may experience modest clinical and cognitive benefits from cognitive remediation. To enhance the clinical impact of cognitive remediation and other rehabilitative interventions for Veterans living with chronic psychosis, this study will develop novel brain-based tools to help identify those Veterans who are most likely to benefit from pro-cognitive therapies. These studies may advance predictive algorithms that improve functional outcomes and life quality in Veterans with schizophrenia.

Key Dates

Start date

Oct 1, 2023

Status verified

Oct 2025

Primary completion

Sep 30, 2028

Completion

Sep 30, 2028

Study Design

Enrollment

80 participants (estimated)

Arms

• Arm: Biomarker Optimization - Patients
  Veterans currently enrolled for healthcare services at the VA San Diego Healthcare System who have a diagnosis of a chronic psychotic disorder (e.g., schizophrenia or schizoaffective disorder).
• Arm: Biomarker Optimization - Healthy Comparison Subjects
  Veterans currently enrolled for healthcare services at the VA San Diego Healthcare System who have no history of mental illness.
• Arm: Biomarker Validation in Chronic Psychotic Disorders
  Veterans currently enrolled for healthcare services at the VA San Diego Healthcare System with a diagnosis of a chronic psychotic disorder (e.g., schizophrenia or schizoaffective disorder).

Primary Outcome Measure

1-week psychometric reliability of Aperiodic Spectral Biomarkers (neurophysiologic biomarker) [ Time Frame: Approximately 7 days ]

Central Contacts

• Juan Molina, MD
  (202) 555-8975
  [email protected]

Locations (1)

Find similar trials in San Diego, CA

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