Comparison of Sepsis Prediction Algorithms

Part of paid clinical trials in Atlanta, Georgia.

Sponsor
Emory University
Study ID
NCT05943938
Status
Not Yet Recruiting

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Conditions

  • Sepsis

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Epic Sepsis Model Version - 1 — OTHER
    The Epic Sepsis Model (ESM) version 1, a proprietary sepsis prediction model.
  • Epic Sepsis Model Version - 2 — OTHER
    The Epic Sepsis Model (ESM) version 2, a proprietary sepsis prediction model.
  • Emory Sepsis Model — OTHER
    Emory internal algorithm

Study Details

Sepsis is a severe response to infection resulting in organ dysfunction and often leading to death. More than 1.5 million people get sepsis every year in the U.S., and 270,000 Americans die from sepsis annually. Delays in the diagnosis of sepsis lead to increased mortality. Several clinical decision support algorithms exist for the early identification of sepsis. The research team will compare the performance of three sepsis prediction algorithms to identify the algorithm that is most accurate and clinically actionable. The algorithms will run in the background of the electronic health record (EHR) and the predictions will not be revealed to patients or clinical staff. In this current evaluation study, the algorithms will not affect any part of a patient's care. The algorithms will be deployed across the Emory healthcare system on data from all patients presenting to the emergency department.

Key Dates

Start date
Jun 30, 2026
Status verified
Dec 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
1,200 participants (estimated)

Arms

  • Arm: ED Patients
    All adult patients presenting to Emergency Departments (ED) in the Emory Healthcare system

Primary Outcome Measure

Patient hospitalization-level area under curve (AUC) for identification of sepsis, [ Time Frame: Duration of hospital stay (until discharge or death), an expected average of 30 days ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Emory Healthcare SystemAtlantaGeorgia30322-
Emory HospitalAtlantaGeorgia30322-
Emory Midtown HospitalAtlantaGeorgia30308
Sivasubramanium Bhavani, MD
[email protected]
(404) 501-1000
Emory Saint Joseph's HospitalAtlantaGeorgia30308-
Emory Decatur HospitalDecaturGeorgia30033
Sivasubramanium Bhavani, MD
[email protected]
404-712-2970
Emory Johns Creek HospitalJohns CreekGeorgia30097-
Emory Hillandale HospitalLithoniaGeorgia30058
Sivasubramanium Bhavani, MD
[email protected]
(404) 501-8000

Find similar trials in Atlanta, GA

By research site
Emory Healthcare System· Atlanta, GAEmory Hospital· Atlanta, GAEmory Midtown Hospital· Atlanta, GAEmory Saint Joseph's Hospital· Atlanta, GAEmory Decatur Hospital· Decatur, GAEmory Johns Creek Hospital· Johns Creek, GA

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