CPI-0209 Plus Carboplatin in Patients With Platinum Sensitive Recurrent Ovarian Cancer

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
Lan Coffman
Study ID
NCT05942300
Phase
PHASE1
Status
Recruiting
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Conditions

  • Recurrent Ovarian Cancer

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • CPI-0209 — DRUG
    A second-generation EZH2 inhibitor that has been designed to achieve comprehensive anti-cancer target coverage through extended on-target residence time.
  • carboplatin — DRUG
    Carboplatin is a chemotherapy drug that contains the metal platinum. It stops or slows the growth of cancer cells and other rapidly growing cells by damaging their DNA.

Study Details

This is a clinical trial using CPI-0209 in combination with Carboplatin chemotherapy followed by CPI-0209 maintenance in patients with platinum sensitive, recurrent ovarian cancer.

Key Dates

Start date
Jan 30, 2024
Status verified
Jun 2025
Primary completion
Nov 1, 2026
Completion
Dec 31, 2028

Study Design

Enrollment
30 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: CPI-0209 (100 mg) + carboplatin
    CPI-0209: 100 mg (oral dosing) carboplatin administered intravenously as per institutional standards
  • Experimental: CPI-0209 (150 mg) + carboplatin
    CPI-0209: 100 mg (oral dosing) carboplatin administered intravenously as per institutional standards

Primary Outcome Measure

Maximum tolerated dose (MTD) of CPI-0209 [ Time Frame: Up to 24 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Magee-Womens Research Institute / UPMC Magee Womens HospitalPittsburghPennsylvania15213
Kelsey Mitch, RN
[email protected]
412-623-6793
Joshua Plassmeyer, MS
[email protected]
412-648-6417
Lan Coffman, MD (PRINCIPAL_INVESTIGATOR)

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By research site
Magee-Womens Research Institute / UPMC Magee Womens Hospital· Pittsburgh, PA

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