A Study of Retatrutide (LY3437943) on Renal Function in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes

Part of paid clinical trials in Chandler, Arizona.

Sponsor
Eli Lilly and Company
Study ID
NCT05936151
Phase
PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Retatrutide — DRUG
    Administered SC
  • Placebo — DRUG
    Administered SC

Study Details

The main purpose of this study is to investigate the effect of retatrutide on renal function in participants with overweight or obesity and chronic kidney disease (CKD), with or without Type 2 Diabetes (T2D). The study will last around 31 weeks.

Key Dates

Start date
Jul 20, 2023
Status verified
Nov 2025
Primary completion
Oct 1, 2025
Completion
Oct 21, 2025

Study Design

Enrollment
146 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Retatrutide
    Participants will receive multiple doses of retatrutide subcutaneously (SC)
  • Placebo Comparator: Placebo
    Participants will receive LY3437943

Primary Outcome Measure

Change from Baseline in Glomerular Filtration Rate (mGFR) [ Time Frame: Baseline, Week 24 ]

Locations (19)

FacilityCityStateZIPSite coordinators
The Institute for Liver Health II dba Arizona Clinical Trials - MesaChandlerArizona85225-
Care Access - 801 South Power Road, MesaMesaArizona85206-
Headlands Research - ScottsdaleScottsdaleArizona85260-
Medical Advancement Centers of ArizonaTempeArizona85283-
Hope Clinical Research, Inc.Canoga ParkCalifornia91303-
Catalina Research Institute, LLCMontclairCalifornia91763-
Peninsula Research AssociatesRolling Hills EstatesCalifornia90274-
University of Colorado Anschutz Medical CampusAuroraColorado80045-
Teradan Clinical Trials, LLCBrandonFlorida33511-
Suncoast Clinical Research, Inc.New Port RicheyFlorida34652-
Great Lakes Clinical Trials - RavenswoodChicagoIllinois60640-
Indiana University Health University HospitalIndianapolisIndiana46202-
Prime Health and Wellness/SKYCRNGFayetteMississippi39069-
Palm Research Center TenayaLas VegasNevada89128-
NYU Langone Hospital - Long IslandMineolaNew York11501-
Cleveland ClinicClevelandOhio44195-
Endocrine Ips, PllcHoustonTexas77079-
Victorium Clinical Research - HoustonHoustonTexas77024-
Tranquility ResearchWebsterTexas77598-

Find similar trials in Chandler, AZ

By condition
Chronic kidney diseaseType 2 diabetes
By specialty
NephrologyKidney diseaseEndocrinologyMetabolic healthWeight loss
By research site
The Institute for Liver Health II dba Arizona Clinical Trials - Mesa· Chandler, AZCare Access - 801 South Power Road, Mesa· Mesa, AZHeadlands Research - Scottsdale· Scottsdale, AZMedical Advancement Centers of Arizona· Tempe, AZHope Clinical Research, Inc.· Canoga Park, CACatalina Research Institute, LLC· Montclair, CA

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