Examining the Role of Female Endogenous Sex Hormones in Eccentric Exercise

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of Southern California
Study ID
NCT05934708
Status
Recruiting
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Conditions

  • Inflammatory Response

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 35 Years
Healthy Volunteers
Accepted

Interventions

  • Eccentric leg extension — BEHAVIORAL
    Participants will complete a 10 x 10 eccentric leg extension on a Cybex Norm dynamometer. Upon arrival, participants will be asked their perceived readiness to perform on a 11 point numeric rating scale. Before the running protocol a baseline blood sample will be collected, as well as passive and active delayed onset muscle soreness (DOMS), a countermovement jump. Half way through each set (i.e., after the 5th repetition) participants will be asked to rank their level of difficulty on a 11 point OMNI Res scale. This will occur during each set. Participants will have follow up blood draws, measures of muscle function (i.e, jump height) and soreness measured immediately after and 24 and 48 hours post-exercise.

Study Details

The fluctuating concentrations of female sex hormones, namely estrogen and progesterone may have an effect on the ability of the tissue to withstand challenging exercise conditions, such as eccentric exercise. These sex hormones have also been purported to influence the perceived difficulty of exercise. This study aims to uncover how the different estrogen and progesterone concentrations present throughout the menstrual cycle effect perceived readiness to perform, perceptions of difficulty, and different recovery metrics.

Key Dates

Start date
Mar 7, 2025
Status verified
Mar 2026
Primary completion
May 30, 2026
Completion
Aug 31, 2026

Study Design

Enrollment
30 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH

Arms

  • Experimental: Low estrogen; low progesterone
    Participants will come in while on their period. During this time estrogen and progesterone concentrations are low.
  • Experimental: High estrogen; low progesterone
    Participants will come in just before ovulation, when estrogen concentrations are high and progesterone concentrations remain low.
  • Experimental: Medium estrogen; high progesterone
    Participants will come in just after ovulation when estrogen concentrations are at a medium level, and progesterone concentrations are high.

Primary Outcome Measure

Preparedness to perform [ Time Frame: Pre exercise ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Clinical Exercise Research CenterLos AngelesCalifornia90033
Bailey McLagan, MS
[email protected]
323-442-2180

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By research site
Clinical Exercise Research Center· Los Angeles, CA

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