Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality

Part of paid clinical trials in New York, New York.

Sponsor
Weill Medical College of Cornell University
Study ID
NCT05925322
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
50 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • "Engage & Connect" Psychotherapy — BEHAVIORAL
    9-weeks of weekly psychotherapy sessions focused on social reward exposure
  • Symptom Review and Psychoeducation (SRP) — BEHAVIORAL
    9-weeks of weekly psychotherapy sessions focused on symptom review and psychoeducation about depression and aging

Study Details

The investigators hypothesized that during the 9-week course of Engage \& Connect treatment there will be an increase in brain functions of the Positive Valence System which in turn will lead to reduction in suicidality.

Key Dates

Start date
Sep 18, 2023
Status verified
Mar 2026
Primary completion
Sep 30, 2028
Completion
Sep 30, 2028

Study Design

Enrollment
128 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: "Engage & Connect" Psychotherapy
    Engage \& Connect is a remotely-delivered psychotherapy, aimed to increase engagement in rewarding social activities and in turn, reduce suicidality. In Engage \& Connect, depressed middle-aged and older adults with suicidal ideation work with a therapist to develop "action plans" to pursue rewarding social activities of their choice.
  • Active Comparator: Symptom Review and Psychoeducation (SRP)
    In this intervention, the therapist will review the participant's symptoms and provide literature-based clinical explanations and clarifications about the symptoms, the course, and the causes of depression and aging processes. In SRP, the therapist reviews the depressed individual's symptoms, and level of information on depression, identifies misconceptions, and guides selection of educational material which could benefit the patient.

Primary Outcome Measure

Change in resting state functional connectivity of the Positive Valence System [ Time Frame: Baseline, midtreatment (week 6) and post treatment (week 9) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Weill Cornell MedicineNew YorkNew York10065
Nili Solomonov, PhD
[email protected]
844-999-8746
Nili Solomonov, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in New York, NY

By condition
Depression
By specialty
PsychiatryMental healthBehavioral health
By research site
Weill Cornell Medicine· New York, NY

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