Adebrelimab, Camrelizumab Plus Apatinib as First-line Therapy in Patients With Advanced Hepatocellular Carcinoma
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Study ID
- NCT05924997
- Phase
- PHASE1/PHASE2
- Status
- Unknown
Conditions
- Advanced Hepatocellular Carcinoma
Eligibility Criteria
- Sex
- ALL
- Age
- 18 Years - N/A
- Healthy Volunteers
- Not accepted
Interventions
- adebrelimab, camrelizumab plus apatinib — DRUGadebrelimab (RP2D, Q3W)+ camrelizumab 200mg Q3W+ apatinib 250mg qd, with 3 weeks (21 days) as a treatment cycle
Study Details
This is a prospective, single-arm, phase Ib/II trial . The objective of this study is to evaluate the efficacy and safety of adebrelimab, camrelizumab plus apatinib as first-line therapy in patients with advanced hepatocellular carcinoma
Key Dates
- Start date
- Jul 1, 2023
- Status verified
- Feb 2024
- Primary completion
- Jun 1, 2025
- Completion
- Jun 1, 2026
Study Design
- Enrollment
- 52 participants (estimated)
- Allocation
- NA
- Intervention model
- SINGLE_GROUP
- Primary purpose
- TREATMENT
Arms
- Experimental: Interventional arm
Primary Outcome Measure
Objective Response Rate [ Time Frame: Up to approximately 2 years ]
Central Contacts
- Lei Zhang, PhD+8613602730646
- Yin Long
Related Studies
- Durvalumab With/Without Tremelimumab After Palliative Hypofractionated Radiotherapy for Hepatocellular CarcinomaPHASE2 · Recruiting · Mary Feng, MD · San Francisco, California
- Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or ThoraxPHASE1 · Recruiting · M.D. Anderson Cancer Center · Houston, Texas
- AU409 for the Treatment of Advanced Primary Liver Cancers or Solid Tumor With Liver Metastatic DiseasePHASE1 · Recruiting · University of Southern California · Los Angeles, California
- A Study of Tegavivint (BC2059) in Patients With Advanced Hepatocellular CarcinomaPHASE1/PHASE2 · Recruiting · Iterion Therapeutics · Duarte, California