HIIT Following Breast Cancer Chemotherapy

Part of paid clinical trials in Gainesville, Florida.

Sponsor
University of Florida
Study ID
NCT05913713
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • 12-week Intervention Period — BEHAVIORAL
    Research participants will be randomly assigned to either high-intensity interval training (HIIT), moderate-intensity continuous training (MICT), or the usual care (UC) group for a 12-week intervention period.
  • 12-week Observation Period — BEHAVIORAL
    After a 12-week intervention period (HIIT, MICT, or UC), research participants will have a 12-week observation period to assess the durability of two types of different exercises.

Study Details

Chemotherapy is an effective breast cancer treatment, which helped to increase the 5-year survival rate to approximately 95%. However, breast cancer survivors have a higher risk of cardiovascular disease (CVD) due to chemotherapy than adults without cancer. Cardiovascular rehabilitation can be an effective strategy to decrease the incidence of CVD and its risk factors in this population. The proposed study may help to examine the effect and durability of a novel high-intensity interval training compared to moderate-intensity continuous training on cardiovascular rehabilitation in breast cancer survivors.

Key Dates

Start date
Mar 7, 2024
Status verified
Nov 2025
Primary completion
May 31, 2026
Completion
May 31, 2026

Study Design

Enrollment
158 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: High Intensity Interval Training (HIIT)
    Supervised home-based high-intensity interval training will be performed on an all-extremity stationary cycle 3 days/week for 12 weeks.
  • Experimental: Moderate Intensity Continuous Training (MICT)
    Supervised home-based moderate-intensity continuous training will be performed on an all-extremity stationary cycle 3 days/week for 12 weeks.
  • Other: Usual Care (UC)
    Research participants will continue their habitual physical activity for the duration of the study. Once they complete the study, they will have the opportunity to perform supervised HIIT or MICT at home for 3 days/week for 12 weeks (research participants can choose either type of exercise).

Primary Outcome Measure

Change in brachial FMD [ Time Frame: Baseline, Following a 12-week intervention period, Following a 12-week observation period ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Integrative Cardiovascular Physiology Laboratory, University of FloridaGainesvilleFlorida32611
Demetra Christou, PhD
[email protected]
352-294-1746

Find similar trials in Gainesville, FL

By condition
Breast cancer
By specialty
OncologyBreast oncologyWomen's health
By research site
Integrative Cardiovascular Physiology Laboratory, University of Florida· Gainesville, FL

Related Studies