The Effects of an Obesogenic Lifestyle in Recreationally Active, Young Adults

Part of paid clinical trials in Durham, New Hampshire.

Sponsor
University of New Hampshire
Study ID
NCT05912348
Status
Recruiting
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Conditions

  • Impaired Glucose Tolerance
  • Insulin Resistance
  • Metabolic Disturbance
  • Obesity

Eligibility Criteria

Sex
ALL
Age
18 Years - 30 Years
Healthy Volunteers
Accepted

Interventions

  • Low Physical Activity and Added Carbohydrate Group — BEHAVIORAL
    Young men and women will transition into a low physically active lifestyle for 10 days and consume added sugar-sweetened beverages. The intervention group will be compared to two control groups and one experimental group. One of the control groups will undergo a low physical activity intervention.
  • Low physical Activity Control — BEHAVIORAL
    Young men and women will transition into a low physically active lifestyle for 10 days.
  • High Physical Activity and Added Carbohydrate Group — BEHAVIORAL
    Young men and women will transition into a high physically active lifestyle for 10 days and consume added sugar-sweetened beverages. The intervention group will be compared to two control groups and one experimental group.

Study Details

This clinical trial aims to learn about the alterations in insulin resistance and metabolic flexibility following a transition to an obesogenic lifestyle in fit young men and women. The main questions it aims to answer are: 1. Does adding excess carbohydrates when transitioning to a sedentary lifestyle promote insulin resistance and impaired 24hr glucose regulation in healthy men and women? 2. Does adding excess carbohydrates when transitioning to a sedentary lifestyle lower the body's ability to break down fats and carbohydrates in healthy men and women? 3. Does the added physical activity blunt shifts in carbohydrate and fat oxidation in healthy men and women?

Key Dates

Start date
Feb 8, 2023
Status verified
Jul 2024
Primary completion
Sep 30, 2026
Completion
Sep 30, 2026

Study Design

Enrollment
45 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Low Physical Activity and Added Carbohydrate Group
    10-days of low physical activity (\~5,000 steps/day) while consuming added sugar-sweetened beverages (\~180 g/day).
  • Placebo Comparator: Low Physical Activity Control
    10-days of sedentary activity (\~5,000 steps/day).
  • No Intervention: Normal Activity Control
    Maintains normal physical activity levels and exercise training
  • Experimental: High Physical Activity and Added Carbohydrate Group
    10-days of high physical activity (\~11,000 steps/day) while consuming added sugar-sweetened beverages (\~180 g/day).

Primary Outcome Measure

To determine if low physical activity alone contributes to insulin resistance in healthy, recreationally active young men and women compared to men and women that reduce their physical activity and consume added sugar-sweetened beverages. [ Time Frame: 10 days ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of New Hampshire Cardiometabolic Research LaboratoryDurhamNew Hampshire03824
Michael Brian, PhD
[email protected]
603-862-1693
Michael Brian, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Durham, NH

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
University of New Hampshire Cardiometabolic Research Laboratory· Durham, NH

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