Ultra-Low Contrast Angiography in AKI

Part of paid clinical trials in New Orleans, Louisiana.

Sponsor
Tulane University
Study ID
NCT05906758
Phase
PHASE3
Status
Recruiting
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Conditions

  • Acute Kidney Injury

Eligibility Criteria

Sex
ALL
Age
18 Years - 100 Years
Healthy Volunteers
Not accepted

Interventions

  • Angiography — PROCEDURE
    Coronary angiography with less than 20cc of contrast materials

Study Details

The aim of this study is to evaluate the safety of ultra-low contrast coronary angiography in patients with pre-existing acute kidney injury.

Key Dates

Start date
Sep 5, 2025
Status verified
May 2026
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
32 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Immediate intervention arm
    Immediate angiography will be performed within 24 hours of enrollment. Omnipaque contrast will be administered. Serum creatinine will be collected on enrollment, within 6 hours before coronary angiography, and at 24h, 48h and 1-week after the angiography, as expected in common practice. Pre- and post-hydration administration will be at the discretion of the treating physician. In case percutaneous coronary intervention is indicated it will be schedule for 7 days after angiography.
  • Placebo Comparator: Delayed intervention arm
    Delayed angiography will be performed after kidney function stabilizes.

Primary Outcome Measure

Change in incidence of Contrast Induced Nephropathy (CIN) [ Time Frame: Within 7 days ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Tulane University Medical CenterNew OrleansLouisiana70112
Zach Rozenbaum, MD
[email protected]
504-988-5493
Zach Rozenbaum, MD (PRINCIPAL_INVESTIGATOR)
University Medical CenterNew OrleansLouisiana70112
Zach Rozenbaum, MD
[email protected]
504-988-5493
Zach Rozenbaum, MD (PRINCIPAL_INVESTIGATOR)

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