Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy

Part of paid clinical trials in St Louis, Missouri.

Sponsor
Washington University School of Medicine
Study ID
NCT05905705
Status
Recruiting
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Conditions

  • Treatment Resistant Depression

Eligibility Criteria

Sex
ALL
Age
21 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Electroencephalography (EEG) — DIAGNOSTIC_TEST
    High-density EEG will be acquired during resting wakefulness before each ECT session.
  • Quantitative Measurements of Sleep Microstructure — DIAGNOSTIC_TEST
    Overnight sleep EEG will be recorded one day before each ECT session using the DREEM device. The DREEM device allows continuous recording of multichannel EEG.

Study Details

Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal.

Key Dates

Start date
Mar 7, 2023
Status verified
Mar 2026
Primary completion
Jul 31, 2027
Completion
Jul 31, 2027

Study Design

Enrollment
50 participants (estimated)

Primary Outcome Measure

Slow wave activity (SWA) during non-rapid eye movement sleep (NREM) stage N2/N3 [ Time Frame: Up to 4 weeks during patients ECT treatment course ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Washington University School of Medicine/Barnes-Jewish HospitalSt LouisMissouri63110
Robby Greenspan
[email protected]
314-273-6129

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By research site
Washington University School of Medicine/Barnes-Jewish Hospital· St Louis, MO

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