Bone-Lead Level Associations With Brain and Mental Health

Conditions

• Lead Exposure

Eligibility Criteria

Sex

ALL

Age

18 Years - 70 Years

Healthy Volunteers

Accepted

Interventions

• X-Ray Fluorescence Analyzer — DEVICE
  The XRF analyzer (the ThermoFisher Niton XL3t GOLDD+) is a portable x-ray fluorescent analyzer specifically configured to measure low levels of metals, lead in particular, in bone. The device is designed to rapidly assess cumulative lead exposure, not to support or sustain human life.

Study Details

The goal of this study is to assess cumulative lead exposure among treatment-seeking patients in the MUSC hospital system receiving experimental transcranial magnetic stimulation (TMS), transcranial direct-current stimulation (tDCS), an electroencephalogram (EEG), and/or transcutaneous auricular vagus nerve stimulation (taVNS) therapies to determine whether lead exposure represents a risk factor for more severe mental illness or a modifier of treatment response. Information will be obtained from patients with a variety of neuropsychiatric disorders recruited to existing hospital studies. This information will include the results of bone-lead testing, brief cognitive tests, and self-reported psychiatric symptoms and behaviors.

Key Dates

Start date

Aug 17, 2023

Status verified

Oct 2025

Primary completion

May 1, 2027

Completion

May 1, 2027

Study Design

Enrollment

500 participants (estimated)

Primary Outcome Measure

Neuropsychiatric Diagnoses [ Time Frame: Baseline ]

Locations (1)

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