iMmune SignAtures and Clinical outComes in AP

Part of paid clinical trials in Los Angeles, California.

Sponsor
Ohio State University
Study ID
NCT05878236
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • CyTOF Analysis — DIAGNOSTIC_TEST
    CyTOF laboratory testing for cytokine levels to correlate with severity of acute pancreatitis

Study Details

The MoSAIC study is a prospective, observational study designed to develop an early prediction tool for severe acute pancreatitis (SAP) and define a distinct immunologic profile compared to moderate acute pancreatitis (MAP). The aims are to validate a new multi-cytokine panel for early prediction of SAP and to identify the specific immune cells that correspond with cytokine signatures in early acute pancreatitis to characterize the immune pathways driving the development of SAP. Participants will provide blood samples and complete patient surveys and interviews within 36 hours of hospital presentation, at 48 hours, and hospital day 7 (if admitted). Data on hospital stay, medical history, clinical course, and severity of disease will be collected.

Key Dates

Start date
Mar 6, 2023
Status verified
Aug 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2027

Study Design

Enrollment
198 participants (estimated)

Arms

  • Arm: Acute Pancreatitis
    Patients meeting Revised Atlanta Criteria for diagnosis of acute pancreatitis

Primary Outcome Measure

Multi-Cytokine Panel Validation [ Time Frame: 4 years ]

Central Contacts

Locations (5)

FacilityCityStateZIPSite coordinators
University of Southern CaliforniaLos AngelesCalifornia90033
Alejandro Vazquez
[email protected]
Dara Bruce
[email protected]
James Buxbaum, MD (PRINCIPAL_INVESTIGATOR)
University of Illinois ChicagoChicagoIllinois60612
Haya Alrashdan, MSN
[email protected]
312-413-0306
Cemal Yazici, MD (PRINCIPAL_INVESTIGATOR)
The Ohio State UniversityColumbusOhio43210
Zoe Krebs, BA
[email protected]
614-685-3619
Samantha Terhorst, MS
[email protected]
614-685-3618
Georgios I Papachristou, MD, PhD (PRINCIPAL_INVESTIGATOR)
Peter J Lee, Mb/ChB (SUB_INVESTIGATOR)
University of PittsburghPittsburghPennsylvania15213
Anna Phillips, MD
[email protected]
412-864-7096
Nicole Ru
[email protected]
4126249310
Anna Phillips, MD (PRINCIPAL_INVESTIGATOR)
Benaroya Research InstituteSeattleWashington98101
Rachel Hartley
[email protected]
206-341-8943
Cate Speake, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Los Angeles, CA

By research site
University of Southern California· Los Angeles, CAUniversity of Illinois Chicago· Chicago, ILThe Ohio State University· Columbus, OHUniversity of Pittsburgh· Pittsburgh, PABenaroya Research Institute· Seattle, WA

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