A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities

Part of paid clinical trials in Chandler, Arizona.

Sponsor
Eli Lilly and Company
Study ID
NCT05869903
Phase
PHASE3
Status
Active Not Recruiting

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Orforglipron — DRUG
    Administered orally.
  • Placebo — DRUG
    Administered orally.

Study Details

This study will investigate the efficacy and safety of once daily oral orforglipron in adult participants with obesity or overweight with weight-related comorbidities. The study has two phases: a main phase and an extension phase. The main phase of the study lasted 72 weeks. Participants with prediabetes will continue in the extension for another 2 years.

Key Dates

Start date
Jun 5, 2023
Status verified
Nov 2025
Primary completion
Jul 25, 2025
Completion
Oct 31, 2027

Study Design

Enrollment
3,127 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Orforglipron Dose 1
    Participants will receive orforglipron administered orally.
  • Experimental: Orforglipron Dose 2
    Participants will receive orforglipron administered orally.
  • Experimental: Orforglipron Dose 3
    Participants will receive orforglipron administered orally.
  • Placebo Comparator: Placebo
    Participants will be given placebo.

Primary Outcome Measure

Mean Percent Change from Baseline in Body Weight [ Time Frame: Baseline to Week 72 ]

Locations (43)

FacilityCityStateZIPSite coordinators
The Institute for Liver Health II dba Arizona Clinical Trials - MesaChandlerArizona85225-
Clinical Research Institute of Arizona (CRI) - Sun City WestSun City WestArizona85375-
John Muir Physician Network Research CenterConcordCalifornia94520-
AMCR InstituteEscondidoCalifornia92025-
NorCal Medical Research, IncGreenbraeCalifornia94904-
Velocity Clinical Research, Huntington ParkHuntington ParkCalifornia90255-
Velocity Clinical Research, WestlakeLos AngelesCalifornia90057-
Catalina Research Institute, LLCMontclairCalifornia91763-
Norcal Endocrinology & Internal MedicineSan RamonCalifornia94583-
University Clinical Investigators, Inc.TustinCalifornia92780-
University of Colorado Anschutz Medical CampusAuroraColorado80045-
New Age Medical Research CorporationMiamiFlorida33186-
South Broward ResearchMiramarFlorida33027-
Renstar Medical ResearchOcalaFlorida34470-
Jedidiah Clinical Research - Tampa - Bay PlazaTampaFlorida33619-
Clinical Site Partners, LLC dba Flourish ResearchWinter ParkFlorida32789-
Physicians Research AssociatesLawrencevilleGeorgia30046-
East Coast Institute for Research, LLCMaconGeorgia31210-
Rophe Adult and Pediatric Medicine/SKYCRNGUnion CityGeorgia30291-
East-West Medical Research InstituteHonoluluHawaii96814-
Elite Clinical TrialsBlackfootIdaho83221-
Cotton O'Neil Clinical Research CenterTopekaKansas66606-
Cotton O'Neil Diabetes & EndocrinologyTopekaKansas66606-
Pennington Biomedical Research CenterBaton RougeLouisiana70808-
Care Access - Lake CharlesLake CharlesLouisiana70601-
MedStar Health Research Institute (MedStar Physician Based Research Network)HyattsvilleMaryland20782-
Endocrine and Metabolic ConsultantsRockvilleMaryland20852-
Arcturus Healthcare , PLC, Troy Internal Medicine Research DivisionTroyMichigan48098-
SKY Integrative Medical Center/SKYCRNGRidgelandMississippi39157-
Las Vegas Medical ResearchLas VegasNevada89128-
Long Island Cardiovascular ConsultantsLake SuccessNew York11042-
Weill Cornell Medical CollegeNew YorkNew York10021-
Alliance for Multispecialty Research, LLCNormanOklahoma73069-
Texas Diabetes & Endocrinology, P.A.AustinTexas78731-
Cedar Health ResearchDallasTexas75251-
Thyroid, Endocrinology, and DiabetesDallasTexas75208-
Velocity Clinical Research, DallasDallasTexas75230-
Juno ResearchHoustonTexas77054-
Consano Clinical Research, LLCShavano ParkTexas78231-
Soma Clinical TrialsWylieTexas75098-
Physicians' Research OptionsDraperUtah84020-
Health Research of Hampton Roads, Inc.Newport NewsVirginia23606-
Eastside Research AssociatesRedmondWashington98052-

Related coverage on Hipa.ai

Find similar trials in Chandler, AZ

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
The Institute for Liver Health II dba Arizona Clinical Trials - Mesa· Chandler, AZClinical Research Institute of Arizona (CRI) - Sun City West· Sun City West, AZJohn Muir Physician Network Research Center· Concord, CAAMCR Institute· Escondido, CANorCal Medical Research, Inc· Greenbrae, CAVelocity Clinical Research, Huntington Park· Huntington Park, CA

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