Immunogenicity of Yellow Fever Vaccine 17D in Adults With Prior 17D Vaccination

Part of paid clinical trials in Portland, Oregon.

Sponsor
Oregon Health and Science University
Study ID
NCT05859490
Phase
PHASE1/PHASE2
Status
Recruiting
Apply to this trial

Conditions

  • Immunization; Infection
  • Yellow Fever

Eligibility Criteria

Sex
ALL
Age
20 Years - 49 Years
Healthy Volunteers
Accepted

Interventions

  • 17D — BIOLOGICAL
    Vaccine administration in subjects previously vaccinated with 17D.

Study Details

The goal of this clinical trial is to assess the immune response to the yellow fever vaccine 17D in adults with prior 17D vaccination. The main questions this study aims to answer are: * how does prior vaccination affect antibody responses to re-vaccination? * how does prior vaccination affect the immune cell response to re-vaccination? Participants will: * have been previously vaccinated with 17D. * be re-vaccinated with 17D. * provide medical and travel histories. * provide a blood sample prior to vaccination * provide a blood sample approximately every other day for 14 days after vaccination. * provide a blood sample approximately 28 days after vaccination. * complete a daily diary of symptoms following vaccination for 14 days. * report any additional symptoms after 14 days.

Key Dates

Start date
Aug 1, 2023
Status verified
Jul 2025
Primary completion
Nov 1, 2025
Completion
Dec 31, 2025

Study Design

Enrollment
35 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION

Arms

  • Experimental: Vaccination arm
    Participants will receive a standard dose of of the yellow fever vaccine 17D (YFVax(r)), 0.5mL suspension in normal saline administered subcutaneously once.

Primary Outcome Measure

Neutralizing antibody titer boost following vaccination [ Time Frame: 28 days ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Oregon Health & Science UniversityPortlandOregon97239
William Messer, MD PhD
[email protected]
503-494-2185
Sarah Siegel, PhD
[email protected]
541-609-0798

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By research site
Oregon Health & Science University· Portland, OR

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