A Study of Combining Cabozantinib and Atezolizumab for Advanced/Metastatic NSCLC (Cabatezo-1)

Part of paid clinical trials in Kansas City, Kansas.

Sponsor
Jun Zhang, MD, PhD
Study ID
NCT05859217
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

  • Advanced NSCLC
  • Lung Cancer
  • Metastatic NSCLC - Non-Small Cell Lung Cancer
  • NSCLC Stage IV

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Cabozantinib — DRUG
    Oral once per day, Days 1 - 21 every 21 days
  • Atezolizumab — DRUG
    Intravenous (IV) once every 21 days

Study Details

NSCLC patients with low expression level of PD-L1, esp. those with its level less than 1%, do not derive much benefit from anti-PD-1/L1 therapy (e.g. atezoilzumab). In this study, investigators hypothesize that the combination of cabozantinib (a multi-kinase inhibitor) and atezolizumab will result in better therapeutic value.

Key Dates

Start date
Dec 31, 2024
Status verified
May 2024
Primary completion
Jun 30, 2026
Completion
Jun 30, 2028

Study Design

Enrollment
40 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Cabozantinib and Atezolizumab
    Cabozantinib 40mg po daily + Atezolizumab 1200mg iv on day 1; 1 cycle = 21 days

Primary Outcome Measure

Objective response rate (ORR) [ Time Frame: through study completion, an average of 1 year ]

Central Contacts

Locations (4)

FacilityCityStateZIPSite coordinators
The University of Kansas Cancer Center - WestwoodKansas CityKansas66205
Clinical Trial Nurse Navigator
[email protected]
913-945-7552
The University of Kansas Cancer Center - Indian CreekOverland ParkKansas66211-
The University of Kansas Cancer Center - NorthKansas CityMissouri64154
Clinical Trial Nurse Navigator
[email protected]
913-945-7552
The University of Kansas Cancer Center - Lee's SummitLee's SummitMissouri64064
Clinical Trial Nurse Navigator
[email protected]
913-945-7552

Find similar trials in Kansas City, KS

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By research site
The University of Kansas Cancer Center - Westwood· Kansas City, KSThe University of Kansas Cancer Center - Indian Creek· Overland Park, KSThe University of Kansas Cancer Center - North· Kansas City, MOThe University of Kansas Cancer Center - Lee's Summit· Lee's Summit, MO

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