The Impact of an Adaptive Patient-centered Web Application on Medication Optimization in HFrEF Patients

Part of paid clinical trials in Atlanta, Georgia.

Sponsor
University of Michigan
Study ID
NCT05858320
Phase
PHASE3
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • SmartHF application — OTHER
    Adaptive medication recommendations that can be shared with the participants HF provider.

Study Details

The SmartHF study is a 12-week prospective randomized controlled multicenter clinical trial. This study will investigate the efficacy of an adaptive web application to facilitate guideline-directed medical therapy (GDMT) optimization in HFrEF patients. Eligible participants will be randomized to the web application intervention or control in a 1:1 manner, stratified by site. The intervention is an adaptive medication optimization web application that extracts and analyzes the EHR data with a computable medication optimization algorithm. The algorithm provides a medication quality score and outputs medication optimization recommendations written in a patient -friendly manner.

Key Dates

Start date
Jul 21, 2023
Status verified
Jan 2026
Primary completion
Dec 1, 2025
Completion
Dec 1, 2025

Study Design

Enrollment
225 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: SmartHF application
    The web application-based study intervention provides adaptive medication recommendations that can be shared with their HF provider.
  • Active Comparator: Control - Patients Standard Medication(s)
    No change to current medication(s)

Primary Outcome Measure

Primary Endpoint: Change in GDMT medication score [ Time Frame: Baseline to Week 12 ]

Locations (5)

FacilityCityStateZIPSite coordinators
Emory University, Grady HospitalAtlantaGeorgia30303-
University of MichiganAnn ArborMichigan48109-
Henry Ford Hospital and Health SystemDetroitMichigan48202-
Trinity Healthcare St. Joseph Mercy Ann ArborYpsilantiMichigan48197-
Washington University, Barns Jewish HospitalSt LouisMissouri63110-

Find similar trials in Atlanta, GA

By condition
Heart failure
By specialty
CardiologyHeart disease
By research site
Emory University, Grady Hospital· Atlanta, GAUniversity of Michigan· Ann Arbor, MIHenry Ford Hospital and Health System· Detroit, MITrinity Healthcare St. Joseph Mercy Ann Arbor· Ypsilanti, MIWashington University, Barns Jewish Hospital· St Louis, MO

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