A Study to Investigate of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle

Conditions

Fentanyl Injection — DRUG
Three different fentanyl doses (used for sedation) will be evaluated on their effects on shear wave elastography (SWE) and breathing

The purpose of this study is to evaluate opioid dose effects on the ability of the diaphragm muscle to generate higher force behaviors.

Experimental: Ultrasound Shear Wave Elastography Examination - Lower
Subjects identified as being administered low dose opioids during an elective lower extremity orthopedic surgery per standard of care will undergo an ultrasound shear wave elastography examination while performing different breathing techniques.
Experimental: Ultrasound Shear Wave Elastography Examination - Mid
Subjects identified as being administered mid dose opioids during an elective lower extremity orthopedic surgery per standard of care will undergo an ultrasound shear wave elastography examination while performing different breathing techniques.
Experimental: Ultrasound Shear Wave Elastography Examination - Higher
Subjects identified as being administered higher dose opioids during an elective lower extremity orthopedic surgery per standard of care will undergo an ultrasound shear wave elastography examination while performing different breathing techniques.

Change in Young's modulus (derived from shear wave speed) [ Time Frame: Baseline, 10 min post-opioid ]

Facility	City	State	ZIP	Site coordinators
Mayo Clinic Minnesota	Rochester	Minnesota	55905	Beth Martin [email protected] 866-265-9263 Brenda Anderson [email protected] 866-265-9263

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