Exercise Neuroprotection in Parkinson's Disease

Part of paid clinical trials in Las Vegas, Nevada.

Sponsor
University of Nevada, Las Vegas
Study ID
NCT05854524
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
30 Years - 85 Years
Healthy Volunteers
Accepted

Interventions

  • Aerobic exercise — PROCEDURE
    The intervention is exercise and there are no drugs or devices used in this trial. The exercise consists of two intensity levels of a 30-minute aerobic exercise intervention with both arms crossing over to both conditions: low intensity exercise (60-70% of estimated maximum heart rate (EMRH)) and moderate-vigorous intensity exercise (75-85% of EMHR).

Study Details

The purpose of this study is to explore the relationships of exercise on inflammation in the body of older adults and people with Parkinson's disease (PD). This is important research for older adults but is especially important for people with PD because neuroinflammation is the main pathological mechanism that is responsible for neuron cell death in this neurodegenerative disease. As PD is a progressive disease, halting or slowing the degeneration is an important research target. Halting or slowing the disease progress is known as neuroprotection. Exercise is an attractive therapeutic treatment for people with PD as it has a lot of multi-systemic benefits, but also there is a lot of evidence to suggest that it helps improve symptoms and slow the progression of the disease. Exercise has been theorized to decrease inflammation and, therefore, has a lot of promise as a neuroprotective agent in slowing or halting the degeneration in PD. Unfortunately, there is not a lot of research that has looked into the effect of exercise on the biological processes of inflammation. Thus, the purpose of this study is to investigate the biological evidence that underlies the positive effect of exercise in people with PD.

Key Dates

Start date
Aug 29, 2024
Status verified
Aug 2024
Primary completion
May 30, 2026
Completion
Dec 30, 2026

Study Design

Enrollment
90 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: Parkinson Disease
    Participants diagnosed with Parkinson disease (PD) will the main arm of the study and will be compared to the control group.
  • Active Comparator: Control
    Older, adults who are age- and sex-matched to the PD participants.

Primary Outcome Measure

Exercise and inflammatory milieu [ Time Frame: Baseline measurement only ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Gait and Balance Laboratory, 217 Bigelow Health Sciences Building, UNLVLas VegasNevada89154
Merrill Landers, PT, DPT, PhD
[email protected]
7028951377
[email protected]
Merrill Landers, PT, DPT, PhD

Find similar trials in Las Vegas, NV

By condition
Parkinson's disease
By specialty
NeurologyBrain disorders
By research site
Gait and Balance Laboratory, 217 Bigelow Health Sciences Building, UNLV· Las Vegas, NV

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