Neurocognitive Abnormalities in Stimulant Abuse Among High-Risk Women

Part of paid clinical trials in Albuquerque, New Mexico.

Sponsor
The Mind Research Network
Study ID
NCT05845333
Status
Recruiting
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Conditions

  • Criminal Behavior
  • Stimulant Abuse

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Decision task — OTHER
    Participants will complete a simple and/or moral decision making functional MRI task.

Study Details

Substance use disorders and psychopathy are serious and costly mental health issues. Psychopathy is known to be associated with aberrant moral decision making and there is considerable interest in determining whether substance use disorders lead to impairments in these same cognitive processes. Recent large-scale research initiatives in forensic settings have begun to identify substance abuse and psychopathy-related disruption in the neural mechanisms involved in moral decision-making processes, and associations between these neural networks and future relapse and antisocial behavior. Here the investigators extend prior work (with incarcerated men) to examine these issues among incarcerated women in order to better understand sex differences. This project addresses the overall lack of neurocognitive research in criminal offenders with substance use disorders, thereby focusing on a major public health issue in an underserved and understudied population.

Key Dates

Start date
Aug 1, 2022
Status verified
May 2025
Primary completion
May 31, 2027
Completion
May 31, 2027

Study Design

Enrollment
334 participants (estimated)

Arms

  • Arm: Stimulant Use Severity High
  • Arm: Stimulant Use Severity Medium
  • Arm: Stimulant Use Severity Low
  • Arm: Psychopathic Traits High
  • Arm: Psychopathic Traits Medium
  • Arm: Psychopathic Traits Low
  • Arm: Community (Healthy) Controls

Primary Outcome Measure

Gray matter volume during MRI scan & stimulant use [ Time Frame: During MRI procedure ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
The Mind Research NetworkAlbuquerqueNew Mexico87106
Carla Harenski
[email protected]
505-272-5028

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By research site
The Mind Research Network· Albuquerque, NM

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