A Study of Microcirculatory Function in Type 2 Myocardial Infarction (T2MI)

Part of paid clinical trials in Rochester, Minnesota.

Sponsor
Mayo Clinic
Study ID
NCT05793567
Status
Not Yet Recruiting

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Conditions

  • Coronary Microvascular Disease
  • Myocardial Infarction

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Coronary angiogram with coronary reactivity testing (CRT) — DIAGNOSTIC_TEST
    CRT is an angiography procedure (using X-ray) to examine the small blood vessels in the heart and how they respond to three drugs (adenosine, acetylcholine and nitroglycerin) as per clinical protocol.

Study Details

The purpose of this research is to find out if patients with Type 2 Myocardial Infarction (T2MI) without significant epicardial coronary artery disease (CAD) have a greater chance of having coronary microvascular disease (CMD).

Key Dates

Start date
Aug 31, 2026
Status verified
Aug 2025
Primary completion
Apr 30, 2027
Completion
Apr 30, 2027

Study Design

Enrollment
52 participants (estimated)

Arms

  • Arm: T2MI Patients
    Patients with T2MI and no epicardial coronary stenosis \>50% will be prospectively enrolled and undergo a routine standard of care coronary angiogram with coronary reactivity testing (CRT).
  • Arm: Controls
    Patients with atypical chest pain and no obstructive disease on coronary angiogram who have been referred for investigation of suspected CMD and have a clinical indication for CMD testing will be retrospectively enrolled and data collected from a previous routine standard of care coronary angiogram with coronary reactivity testing (CRT) will be utilized.

Primary Outcome Measure

Coronary Flow Reserve (CFR) [ Time Frame: Baseline ]

Central Contacts

  • Ischemic Heart Disease Research Team
    507-255-1724
  • Claire Raphael, MBBS, PhD
    507-255-2445
    [email protected]

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo Clinic RochesterRochesterMinnesota55905
Ischemic Heart Disease Research Team
507-255-1724
Claire Raphael, MBBS, PhD
[email protected]
507-255-2445
Claire Raphael, MBBS, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Mayo Clinic Rochester· Rochester, MN

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