Safety, Parameterization, and Mechanism of Transcranial Focused Ultrasound

Part of paid clinical trials in Charleston, South Carolina.

Sponsor
Medical University of South Carolina
Study ID
NCT05792020
Status
Not Yet Recruiting

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Conditions

  • Healthy

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • Focused Ultrasound Stimulation — DEVICE
    This aim will test whether motor tFUS parameters thought to be excitatory (50% duty cycle) vs. inhibitory (5% duty cycle) elicit their predicted effects on MEPs before and after each of three stimulation blocks, using 50 MEPs at each time point.

Study Details

Through the BrainBox Initiative, investigators propose to study the effects of motor tFUS on Motor Evoked Potentials (MEPs) and GABA and Glutamate Concentrations in the Brain.

Key Dates

Start date
Jul 31, 2026
Status verified
May 2026
Primary completion
Dec 31, 2027
Completion
Dec 31, 2028

Study Design

Enrollment
25 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Excitatory tFUS parameters effect on Motor Evoked Potentials
    All participants will receive three sessions of Focused Ultrasound Stimulation to their motor hotspot. This stimulation cycle will operate at a 50% duty cycle.
  • Experimental: Inhibitory tFUS parameters effect of Motor Evoked Potentials
    All participants will receive three sessions of Focused Ultrasound Stimulation to their motor hotspot. This stimulation cycle will operate at a 5% duty cycle
  • Sham Comparator: Sham tFUS parameters effect of Motor Evoked Potentials
    All participants will receive three sessions of Focused Ultrasound Stimulation to their motor hotspot. This stimulation cycle will utilize an air-filled spacer to block stimulation from reaching the brain

Primary Outcome Measure

Motor Evoked Potential Amplitude [ Time Frame: Immediate Post-Stimulation ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Medical University of South CarolinaCharlestonSouth Carolina29425
Lisa M McTeague, PhD
[email protected]
(843) 792-8274
Allison K Wilkerson, PhD
[email protected]
843-792-4636

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By research site
Medical University of South Carolina· Charleston, SC

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