Ovarian PRP for Diminished Ovarian Reserve

Conditions

• Diminished Ovarian Reserve

Eligibility Criteria

Sex

FEMALE

Age

35 Years - 42 Years

Healthy Volunteers

Accepted

Interventions

• oPRP — OTHER
  Prepared sample from patient's own blood collected and processed. Either PRP or serum is injected into the patient's ovary. All other care is standard for the IVF process
• Placebo- Serum — OTHER
  Patient's serum is injected into ovary instead of PRP as placebo

Study Details

This prospective double-blinded randomized placebo control study aims to determine if In Vitro Fertilization (IVF) outcomes are improved by ovarian platelet-rich plasma injections (oPRP) for women diagnosed with diminished ovarian reserve (DOR). Women with DOR notoriously have the lowest chance of pregnancy and live birth compared to age-matched peers with a normal or robust ovarian reserve.

Key Dates

Start date

Oct 7, 2023

Status verified

Feb 2025

Primary completion

Mar 1, 2025

Completion

Dec 31, 2025

Study Design

Enrollment

230 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: oPRP injections
  Patients own prepared PRP will be injected into each ovary
• Placebo Comparator: Placebo
  Patient's serum will be injected into the ovary (not rich with platelets)

Primary Outcome Measure

oPRP changes Ovarian Response and the total Number of oocytes retrieved [ Time Frame: 12 months ]

Central Contacts

• Alicia Broussard, PhD
  3174456958
  [email protected]
• Jesse Hade, MD
  2126410906
  [email protected]

Locations (1)

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