Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Markers of Aging in Older Adults

Conditions

• Aging
• Diabetes Mellitus, Type 2
• Overweight and Obesity
• PreDiabetes

Eligibility Criteria

Sex

ALL

Age

65 Years - 90 Years

Healthy Volunteers

Not accepted

Interventions

• Semaglutide Injectable Product — DRUG
  Semaglutide will be started at 0.25mg once a week for 4 weeks followed by 0.5mg once weekly for 4 weeks followed by 1.0mg once a week for 12 weeks.
• Lifestyle Counseling — BEHAVIORAL
  Lifestyle Counseling will be provided throughout study intervention

Study Details

Semaglutide is a medication approved by the US Food and Drug Administration (FDA) as an antihyperglycemic (a drug that reduces glucoses in those with diabetes) and for weight management. This new study will help find out what effects, semaglutide has on people who take the drug and the drug's effect on physical function, body composition, and aging.

Key Dates

Start date

Apr 1, 2023

Status verified

Apr 2025

Primary completion

May 20, 2024

Completion

May 20, 2024

Study Design

Enrollment

20 participants (actual)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Semaglutide and lifestyle intervention
  Participants will meet with a dietician throughout the study to discuss lifestyle counseling based on recommendation in the diabetes prevention program. They will also be given semaglutide for 20 weeks.
• Active Comparator: Lifestyle intervention
  Participants will meet with a dietician throughout the study to discuss lifestyle counseling based on recommendation in the diabetes prevention program

Primary Outcome Measure

Lean Body Mass Change [ Time Frame: Baseline to 20 weeks ]

Locations (1)

Related coverage on Hipa.ai

• Semaglutide Trial Shows Greater Lean Body Mass Reduction in Older Adults
  Semaglutide · May 4, 2025 · ClinicalTrials.gov

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