PET/CT Imaging to Evaluate Cardiac Radiation Damage in Patients With Lung or Esophageal Cancer, EUCLID Trial

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
Thomas Jefferson University
Study ID
NCT05775939
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Fludeoxyglucose F-18 — OTHER
    Given FDG
  • Positron Emission Tomography — PROCEDURE
    Undergo PET-CT
  • Computed Tomography — PROCEDURE
    Undergo PET-CT
  • Questionnaire Administration — OTHER
    Ancillary studies

Study Details

This clinical trial examines positron emission tomography (PET)/computed tomography (CT) in evaluating cardiac radiation damage in patients with lung or esophageal cancer. As part of the treatment for lung or esophageal cancer, patients will undergo radiation therapy. Sometimes, during this treatment, the heart is also subjected to some radiation which could affect its function, either increasing or decreasing the function. It is not known the consequences of this change nor is it known if doctors can detect the changes associated with the radiation. Sarcoidosis FDG positron emission tomography (PET)-computed tomography (CT) scans are a common way to image cardiac inflammation and myocardial viability. This study may help doctors image the heart before, during and after radiotherapy to monitor any changes.

Key Dates

Start date
Jan 20, 2023
Status verified
Feb 2026
Primary completion
Jul 1, 2027
Completion
Jul 1, 2028

Study Design

Enrollment
20 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: Diagnostic (sarcoidosis FDG PET-CT)
    Patients undergo sarcoidosis FDG PET-CT of the heart before, during and, after radiotherapy.

Primary Outcome Measure

Change in mean standardized uptake value (SUV) changes in the heart [ Time Frame: Up to 30 months after radiotherapy ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Thomas Jefferson University HospitalPhiladelphiaPennsylvania19107
Yevgeniy Vinogradskiy, MD
[email protected]
215-955-3605

Find similar trials in Philadelphia, PA

By condition
Esophageal cancerLung cancer
By specialty
OncologyGI oncologyLung oncologyLung disease
By research site
Thomas Jefferson University Hospital· Philadelphia, PA

Related Studies