Amygdala Neurofeedback for Depression - Large Scale Clinical Trial

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
Kymberly Young
Study ID
NCT05703256
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Not accepted

Interventions

  • Amygdala real-time fMRI neurofeedback — DEVICE
    Participants are shown activity from their left amygdala in real time and are instructed to increase the level of activity in that region by thinking of positive autobiographical memories
  • Sham feedback — DEVICE
    Participants are shown activity from another participant's left amygdala who previously completed the task and are instructed to increase the level of activity in that region by thinking of positive autobiographical memories

Study Details

The goal of this study is to evaluate whether rtfMRI-nf training to increase the amygdala response to positive memories may serve as a stand-alone intervention for major depressive disorder

Key Dates

Start date
Jun 1, 2023
Status verified
Mar 2026
Primary completion
Apr 30, 2027
Completion
Apr 30, 2028

Study Design

Enrollment
200 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Amygdala real-time fMRI neurofeedback
    Amygdala neurofeedback - attempt to upregulate the left amygdala during positive autobiographical memory recall via real time fMRI neurofeedback from the amygdala. Two sessions will be performed one week apart.
  • Sham Comparator: Sham feedback
    Yoked sham - participants will see the amygdala activity of another subject who completed the intervention. Two sessions will be performed one week apart.

Primary Outcome Measure

Beck Depression Inventory (BDI-II) [ Time Frame: baseline vs up to one year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of PittsburghPittsburghPennsylvania15261
Kymberly Young, PhD
[email protected]

Find similar trials in Pittsburgh, PA

By condition
Depression
By specialty
PsychiatryMental healthBehavioral health
By research site
University of Pittsburgh· Pittsburgh, PA

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