A Study of Short-Course Radiation Therapy With Chemotherapy in People With Endometrial Cancer

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT05691010
Phase
EARLY_PHASE1
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Intensity-modulated radiation therapy — RADIATION
    After cycles 1, 2, 3 or 4 of chemotherapy, patients will receive IMRT to the vaginal cuff and pelvic lymph nodes with a total dose of 25 Gy delivered in 5 daily fractions of 5 Gy
  • Carboplatin — DRUG
    Patients enrolled in this trial will receive chemotherapy with carboplatin IV AUC 5 at the discretion of the treating investigator plus paclitaxel 175 mg/m2 every 21 days for 6 cycles
  • Paclitaxel — DRUG
    Patients enrolled in this trial will receive chemotherapy with carboplatin IV AUC 5 at the discretion of the treating investigator plus paclitaxel 175 mg/m2 every 21 days for 6 cycles

Study Details

The purpose of this study is to find out whether short-course radiation therapy (1 week instead of the usual 5 weeks) with chemotherapy (carboplatin and paclitaxel) is practical (feasible), meaning that most participants are able to complete the treatment schedule.

Key Dates

Start date
Jan 10, 2023
Status verified
Feb 2026
Primary completion
Jan 10, 2027
Completion
Jan 10, 2027

Study Design

Enrollment
28 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Participants with Endometrial Cancer
    Participants have stage III endometrial cancer

Primary Outcome Measure

Feasibility of integrated delivery of short-course IMRT with carboplatin/paclitaxel in patients with stage III endometrial cancer [ Time Frame: up to 3 years ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering Basking Ridge (All protocol activities)Basking RidgeNew Jersey07920
Kalad Alektiar, MD
212-639-7981
Memorial Sloan Kettering Monmouth (All protocol activities)MiddletownNew Jersey07748
Kaled Alektiar, MD
212-639-7981
Memorial Sloan Kettering Bergen (All protocol activities)MontvaleNew Jersey07645
Kaled Alektiar, MD, MSc
212-639-7981
Memorial Sloan Kettering Commack (All protocol activities)CommackNew York11725
Kaled Alektiar, MD
212-639-7981
Memorial Sloan Kettering Westchester (All protocol activities)HarrisonNew York10604
Kaled Alektiar, MD
212-639-7981
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065
Kaled Alektiar, MD
212-639-7981
Samuel Singer, MD
212-639-2164
Memorial Sloan Kettering Nassau (All protocol activities)UniondaleNew York11553
Kaled Alektiar, MD
212-639-7981

Find similar trials in Basking Ridge, NJ

By condition
Endometrial cancer
By specialty
OncologyGynecologic oncologyWomen's health
By research site
Memorial Sloan Kettering Basking Ridge (All protocol activities)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (All protocol activities)· Middletown, NJMemorial Sloan Kettering Bergen (All protocol activities)· Montvale, NJMemorial Sloan Kettering Commack (All protocol activities)· Commack, NYMemorial Sloan Kettering Westchester (All protocol activities)· Harrison, NYMemorial Sloan Kettering Cancer Center· New York, NY

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