Mechanisms of Risky Alcohol Use in Young Adults: Linking Sleep to Reward- and Stress-Related Brain Function

Conditions

• Alcohol Use Disorder

Eligibility Criteria

Sex

ALL

Age

18 Years - 24 Years

Healthy Volunteers

Not accepted

Interventions

• Sleep extension and advance — BEHAVIORAL
  Participants in the sleep extension and advance condition will maintain a stable sleep schedule that extends sleep duration and advances bedtime by 90 min relative to weekday bedtime. This chronotherapeutic manipulation will include blocking phase-delaying light in the evening using goggles with orange lenses ("blue blockers") beginning 2 h prior to bedtime, and 30 min of 506 lux blue-green light exposure in the morning beginning at rise time using bright light goggles (ReTimer Pty Ltd., Australia). Schedule and chronotherapy adherence will be reinforced using motivational techniques (e.g., securing motivation, preplanning, problem-solving), requiring participants to text the study coordinator and complete morning assessments at rise time, and monetary incentives.
• Regular sleep duration and timing — BEHAVIORAL
  Participants in the regular sleep duration and timing condition will keep a stable sleep schedule that matches their typical weekday sleep opportunity and timing. Schedule adherence will be reinforced using motivational techniques (e.g., securing motivation, preplanning, problem-solving), requiring participants to text the study coordinator and complete morning assessments at rise time, and monetary incentives.

Study Details

This research will use biobehavioral approaches to generate understanding about the linkages between stressful life events, sleep duration and timing, and alcohol use in young adults, with a long-term aim of developing effective preventative interventions for alcohol use disorders.

Key Dates

Start date

Sep 7, 2023

Status verified

Feb 2026

Primary completion

Feb 28, 2027

Completion

Feb 28, 2027

Study Design

Enrollment

90 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Sleep extension and advance "Lark Routine"
  Participants go to bed 90 minutes earlier than their typical average bedtime to extend sleep duration and advance sleep timing
• Active Comparator: Regular sleep duration and timing "Owl Routine"
  Participants go to bed at their typical average bedtime

Primary Outcome Measure

Alcohol use [ Time Frame: 2 months ]

Central Contacts

• Amanda Johnson
  541-346-4107
  [email protected]

Locations (1)

Find similar trials in Eugene, OR

Related Studies

• Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder
  PHASE4 · Recruiting · Milky Kohno · Portland, Oregon
• TMS to Improve Recovery Outcomes Among Patients With Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD)
  Recruiting · Washington State University · Portland, Oregon
• Safety and Effectiveness of the BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for Treatment of Alcohol Use Disorder (AUD)
  Recruiting · Brainsway · Tuscaloosa, Alabama
• Behavioral and Functional Task Development, Implementation, and Testing
  Recruiting · National Institute on Alcohol Abuse and Alcoholism (NIAAA) · Bethesda, Maryland