Stereotactic Body Radiation and Tumor Treating Fields for Locally Advanced Pancreas Cancer

Part of paid clinical trials in Miami, Florida.

Sponsor
Baptist Health South Florida
Study ID
NCT05679674
Status
Recruiting
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Conditions

  • Locally Advanced
  • Locally Advanced Pancreatic Adenocarcinoma
  • Pancreas Cancer

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Stereotactic Ablative Body Radiation (SABR) — RADIATION
    50 Gy in 5 fractions, once per day for 5 days
  • Tumor Treating Fields (TTF) — DEVICE
    Participant will use the system for at least 18 hours per day starting on the first day of SABR until abdominal disease progression. Short treatment breaks are permitted for personal needs (such as to take a shower) and during radiation therapy. An additional treatment break is permitted for up to 48 hours every 21 days.

Study Details

The purpose of this clinical trial is to determine whether using chemotherapy followed by stereotactic ablative body radiation therapy (SABR) and tumor treating fields (TTF) will slow tumor growth in people with locally advanced pancreas cancer. All participants will receive SABR therapy once per day for five days and use the TTF system for at least 18 hours per day starting on the first day of SABR until the tumor progresses or severe toxicity develops.

Key Dates

Start date
Sep 21, 2023
Status verified
Jan 2026
Primary completion
Jun 30, 2027
Completion
Jun 30, 2027

Study Design

Enrollment
48 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Stereotactic Ablative Body Radiation (SABR) and Tumor Treating Fields (TTF)
    50 Gy in five fractions SABR (once per day for 5 days) and use of the TTF system for 18 hours per day starting on the first day of SABR and continuing until abdominal disease progression

Primary Outcome Measure

Median Progression Free Survival (PFS) [ Time Frame: 2 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Miami Cancer Institute at Baptist Health, Inc.MiamiFlorida33176
Michael Chuong, M.D.
[email protected]
786-596-2000

Find similar trials in Miami, FL

By research site
Miami Cancer Institute at Baptist Health, Inc.· Miami, FL

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