Effects of Exercise on Dystonia Pathophysiology

Part of paid clinical trials in Gainesville, Florida.

Sponsor
University of Florida
Study ID
NCT05663840
Status
Recruiting
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Conditions

  • Dystonia

Eligibility Criteria

Sex
ALL
Age
30 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • Progressive resistance exercise — BEHAVIORAL
    Patients with predominant symptoms of cervical dystonia will receive exercise training. Patients will receive progressive resistance exercise focused cervical and shoulder training (PERFECT) plus standard-of-care (SOC) therapy. Resistance training will consist of mainly muscle-strengthening exercises for the neck, shoulder and arms and a few upper trunk muscles. Resistance training will be guided by physical therapists at twice a week schedule for 6 months. These participants will also receive SOC therapy.
  • Standard of care — BEHAVIORAL
    Subjects will receive SOC therapy only

Study Details

The purpose of this research study is to investigate how the brain and motor behavior changes in individuals with dystonia in response to exercise training.

Key Dates

Start date
Oct 13, 2022
Status verified
Jun 2025
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
56 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Progressive resistance exercise (exercise group)
    Subjects will receive physical therapy that will predominantly include progressive resistance exercise training program along with continuation of standard of care (exercise group)
  • Active Comparator: Standard of care (non-exercise group).
    Subjects will receive continuation of standard of care (non-exercise group).

Primary Outcome Measure

Brain effects measured with fMRI [ Time Frame: Baseline up to 6 months ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of FloridaGainesvilleFlorida32611
Aparna Wagle Shukla, MD
[email protected]
352-273-5550
Aparna Wagle Shukla, MD (PRINCIPAL_INVESTIGATOR)

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By research site
University of Florida· Gainesville, FL

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