A Study of Targeted Radiation Therapy in People With Non-Small Cell Lung Cancer (NSCLC)

Part of paid clinical trials in Miami, Florida.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT05657873
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • L-SABR — RADIATION
    L-SABR will be delivered in a week during which the patient receives no chemotherapy. L-SABR can be on the same week or even day as anti-PD-(L)1 therapy.
  • Anti-PD-(L)1 based immunotherapy — BIOLOGICAL
    Standard of care treatment (anti-PD-(L)1 based immunotherapy +/- platinum based chemotherapy
  • Platinum based chemotherapy — DRUG
    Standard of care treatment (anti-PD-(L)1 based immunotherapy +/- platinum based chemotherapy

Study Details

The purpose of this study is to see whether adding liver stereotactic ablative radiotherapy/L-SABR to standard drug therapy is better than standard drug therapy alone for people with metastatic non-small cell lung cancer/NSCLC.

Key Dates

Start date
Dec 9, 2022
Status verified
May 2026
Primary completion
Dec 9, 2026
Completion
Dec 9, 2026

Study Design

Enrollment
68 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: L-SABR Arm
    Participants randomized to the experimental arm will continue with standard of care treatment but will also undergo radiation simulation for L-SABR/Liver Stereotactic Ablative Radiation Therapy.
  • Active Comparator: Control Arm
    Participants randomized to the control arm will be treated according to the standard of care.

Primary Outcome Measure

Median progression-free survival [ Time Frame: up to 4 years ]

Central Contacts

Locations (9)

FacilityCityStateZIPSite coordinators
BAPTIST ALLIANCE - MCI (Data Collection Only)MiamiFlorida33143
Adeel Kaiser, MD
786-596-2000
Memorial Sloan Kettering at Basking Ridge (All Protocol Activities)Basking RidgeNew Jersey07920
Paul Romeser, MD
646-888-2118
Memorial Sloan Kettering Monmouth (All Protocol Activities)MiddletownNew Jersey07748
Paul Romesser, MD
646-888-2118
Memorial Sloan Kettering Bergen (All protocol activities)MontvaleNew Jersey07645
Paul Romesser, MD
646-888-2118
Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)CommackNew York11725
Paul Romesser, MD
646-888-2118
Memorial Sloan Kettering Westchester (All Protocol Activities)HarrisonNew York10604
Paul Romesser, MD
646-888-2118
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New YorkNew York10065
Paul Romesser, MD
646-888-2118
Memorial Sloan Kettering Nassau (All protocol activities)Rockville CentreNew York11553
Paul Romesser, MD
646-888-2118
Lehigh Valley Health Network (Data Collection Only)AllentownPennsylvania18103
Dennis Sopka, MD
610-402-0700

Find similar trials in Miami, FL

By condition
Lung cancer
By specialty
OncologyLung oncologyLung disease
By research site
BAPTIST ALLIANCE - MCI (Data Collection Only)· Miami, FLMemorial Sloan Kettering at Basking Ridge (All Protocol Activities)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (All Protocol Activities)· Middletown, NJMemorial Sloan Kettering Bergen (All protocol activities)· Montvale, NJMemorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)· Commack, NYMemorial Sloan Kettering Westchester (All Protocol Activities)· Harrison, NY

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