Adaptive Trial Scheduling in Naming Treatment for Aphasia

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
University of Pittsburgh
Study ID
NCT05653466
Phase
PHASE2
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Adaptive Spacing Condition — BEHAVIORAL
    Each of the 200 target words for practice are presented on a schedule determined by an algorithm that relies on the pattern of correct vs. incorrect responses for each item. Items in the "active learning" state need to be answered correctly a certain number of times before being categorized as "learned." Each item must be answered correctly 3 times in a row (immediately, then at one-minute and five-minute intervals) before it is categorized as "learned." Then, it will be scheduled at ever-increasing intervals, until answered incorrectly, at which point the item would be returned to the "active learning" state, requiring three correct responses in a row to return again to the "learned" expanding interval state.
  • High-Item Non-Adaptive Spacing Condition — BEHAVIORAL
    Each of the 200 target words for practice are presented in sequential order randomized within blocks, with each word presented once before the list repeats.
  • Low-Item Non-Adaptive Spacing Condition — BEHAVIORAL
    Each of the 40 target words for practice are presented in sequential order randomized within blocks, with each word presented once before the list repeats.

Study Details

Aphasia is a language disorder caused by stroke and other acquired brain injuries that affects over two million people in the United States and which interferes with life participation and quality of life. Anomia (i.e., word- finding difficulty) is a primary frustration for people with aphasia. Picture-based naming treatments for anomia are widely used in aphasia rehabilitation, but current treatment approaches do not address the long-term retention of naming abilities and do not focus on using these naming abilities in daily life. The current research aims to evaluate novel anomia treatment approaches to improve long-term retention and generalization to everyday life. This study is one of two that are part of a larger grant. This record is for sub-study 2, which will evaluate the benefits of adaptive trial spacing.

Key Dates

Start date
Dec 6, 2023
Status verified
Dec 2025
Primary completion
Jan 31, 2027
Completion
Jan 31, 2028

Study Design

Enrollment
32 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: Adaptive spacing, then high-item non-adaptive spacing, then low-item non-adaptive spacing
    All participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions.
  • Experimental: Adaptive spacing, then low-item non-adaptive spacing, then high-item non-adaptive spacing
    All participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions.
  • Experimental: High-item non-adaptive spacing, then adaptive spacing, then low-item non-adaptive spacing
    All participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions.
  • Experimental: High-item non-adaptive spacing, then low-item non-adaptive spacing, then adaptive spacing
    All participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions.
  • Experimental: Low-item non-adaptive spacing, then high-item non-adaptive spacing, then adaptive spacing
    All participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions.
  • Experimental: Low-item non-adaptive spacing, then adaptive spacing, then high-item non-adaptive spacing
    All participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions.

Primary Outcome Measure

Change in correct responses in Confrontation Naming of Treated and Untreated Pictured Objects [ Time Frame: Initial assessment (pre-treatment), 3 months post-treatment ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Language Rehab and Cognition Lab, Department of Communication Sciences and Disorders, School of Health and Rehabilitation Sciences, University of PittsburghPittsburghPennsylvania15260
William Evans, PhD
[email protected]
412-383-6943
William Evans, PhD (PRINCIPAL_INVESTIGATOR)

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By specialty
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By research site
Language Rehab and Cognition Lab, Department of Communication Sciences and Disorders, School of Health and Rehabilitation Sciences, University of Pittsburgh· Pittsburgh, PA

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