A Study to Evaluate the Efficacy and Safety of Povorcitinib (INCB054707) in Participants With Moderate to Severe Hidradenitis Suppurativa (HS)

Part of paid clinical trials in Scottsdale, Arizona.

Sponsor
Incyte Corporation
Study ID
NCT05620836
Phase
PHASE3
Status
Completed

Conditions

  • Hidradenitis Suppurativa (HS)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Povorcitinib — DRUG
    Oral, Tablet
  • Placebo — DRUG
    Oral, Tablet

Study Details

The purpose of this study is to evaluate the efficacy and safety of Povorcitinib (INCB054707) in participants with moderate to severe Hidradenitis Suppurativa (HS) over a 12-week placebo-controlled period, followed by a 42-week extension period.

Key Dates

Start date
Feb 22, 2023
Status verified
Jan 2026
Primary completion
Jan 7, 2025
Completion
Nov 21, 2025

Study Design

Enrollment
619 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Povorcitinib Dose A
    Participants will receive Povorcitinib Dose A for 54 weeks.
  • Experimental: Povorcitinib Dose B
    Participants will receive Povorcitinib Dose B for 54 weeks.
  • Placebo Comparator: Placebo
    Participants will receive Placebo for 12 weeks, followed by Povorcitinib (Dose A or Dose B) for 42 weeks.

Primary Outcome Measure

Proportion of participants who achieve Hidradenitis Suppurativa Clinical Response (HiSCR) [ Time Frame: Week 12 ]

Locations (38)

FacilityCityStateZIPSite coordinators
Investigative Site US237ScottsdaleArizona85259-
Investigative Site US240ScottsdaleArizona85255-
Investigative Site US214Arkansas CityArkansas72758-
Investigative Site US242FayettevilleArkansas72703-
Investigative Site US223Los AngelesCalifornia90033-
Investigative Site US226San DiegoCalifornia92103-
Investigative Site US222San FranciscoCalifornia94118-
Investigative Site US233Washington D.C.District of Columbia20060-
Investigative Site US228BrandonFlorida33511-
Investigative Site US227MargateFlorida33063-
Investigative Site US204MiamiFlorida33125-
Investigative Site US236MiamiFlorida33173-
Investigative Site US200OcalaFlorida34470-
Investigative Site US201TampaFlorida33613-
Investigative Site US220West DundeeIllinois60118-
Investigative Site US206IndianapolisIndiana46250-
Investigative Site US241Iowa CityIowa52242-
Investigative Site US209LouisvilleKentucky40241-
Investigative Site US207MetairieLouisiana70006-
Investigative Site US229New OrleansLouisiana70115-
Investigative Site US224BaltimoreMaryland21224-
Investigative Site US208BeverlyMassachusetts01915-
Investigative Site US221QuincyMassachusetts02169-
Investigative Site US213DetroitMichigan48084-
Investigative Site US217WaterfordMichigan48328-
Investigative Site US212MinneapolisMinnesota55455-
Investigative Site US239OmahaNebraska68144-
Investigative Site US230HightstownNew Jersey08520-
Investigative Site US202New YorkNew York10003-
Investigative Site US210RochesterNew York14642-
Investigative Site US205Chapel HillNorth Carolina27516-
Investigative Site US215BexleyOhio43209-
Investigative Site US203ColumbusOhio43210-
Investigative Site US232MurfreesboroTennessee37130-
Investigative Site US235ArlingtonTexas76011-
Investigative Site US218BellaireTexas77401-
Investigative Site US238PflugervilleTexas78660-
Investigative Site US234San AntonioTexas78213-

Find similar trials in Scottsdale, AZ

By research site
Investigative· Scottsdale, AZInvestigative· Arkansas City, ARInvestigative· Fayetteville, ARInvestigative· Los Angeles, CAInvestigative· San Diego, CAInvestigative· San Francisco, CA

Related Studies