A Study to Evaluate the Efficacy and Safety of Povorcitinib (INCB054707) in Participants With Moderate to Severe Hidradenitis Suppurativa

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
Incyte Corporation
Study ID
NCT05620823
Phase
PHASE3
Status
Completed

Conditions

  • Hidradenitis Suppurativa (HS)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Povorcitinib — DRUG
    Oral; Tablet
  • Placebo — DRUG
    Oral; Tablet

Study Details

The purpose of this study is to evaluate the efficacy and safety of Povorcitinib (INCB054707) in participants with moderate to severe Hidradenitis Suppurativa (HS) over a 12-week placebo controlled period, followed by a 42-week extension period.

Key Dates

Start date
Dec 19, 2022
Status verified
Feb 2026
Primary completion
Feb 3, 2025
Completion
Dec 23, 2025

Study Design

Enrollment
608 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Povorcitinib Dose A
    Participants will receive Povorcitinib Dose A for 54 weeks.
  • Experimental: Povorcitinib Dose B
    Participants will receive Povorcitinib Dose B for 54 weeks.
  • Placebo Comparator: Placebo
    Participants will receive Placebo for 12 weeks, followed by Povorcitinib (Dose A or Dose B) for 42 weeks.

Primary Outcome Measure

Proportion of participants who achieve Hidradenitis Suppurativa Clinical Response (HiSCR) [ Time Frame: Week 12 ]

Locations (37)

FacilityCityStateZIPSite coordinators
Investigative Site US303PhoenixArizona85006-
Investigative Site US335Arkansas CityArkansas72758-
Investigative Site US307Fort SmithArkansas72916-
Investigative Site US315Laguna NiguelCalifornia92677-
Investigative Site US326Los AngelesCalifornia90045-
Investigative Site US323San FranciscoCalifornia94118-
Investigative Site US306Boca RatonFlorida33486-
Investigative Site US320Boca RatonFlorida33486-
Investigative Site US317HialeahFlorida33012-3618-
Investigative Site US338MargateFlorida33063-
Investigative Site US321North Miami BeachFlorida33162-4708-
Investigative Site US316OrlandoFlorida32819-
Investigative Site US328TampaFlorida33612-
Investigative Site US336TampaFlorida33613-
Investigative Site US311MariettaGeorgia30060-1047-
Investigative Site US327ChicagoIllinois60612-
Investigative Site US319SkokieIllinois60077-
Investigative Site US337IndianapolisIndiana46250-
Investigative Site US341Bowling GreenKentucky42103-
Investigative Site US334MetairieLouisiana70006-
Investigative Site US333BaltimoreMaryland21287-
Investigative Site US325ColumbiaMaryland21045-
Investigative Site US318BeverlyMassachusetts01915-
Investigative Site US304BostonMassachusetts02215-
Investigative Site US310BrightonMassachusetts02135-
Investigative Site US302St LouisMissouri63110-
Investigative Site US331AlbuquerqueNew Mexico87102-
Investigative Site US324Kew GardensNew York11415-
Investigative Site US339BexleyOhio43209-
Investigative Site US330BoardmanOhio44512-
Investigative Site US314CincinnatiOhio45219-
Investigative Site US312ClevelandOhio44106-
Investigative Site US301PortlandOregon97223-
Investigative Site US340BellaireTexas77401-
Investigative Site US300PlanoTexas75025-
Investigative Site US313NorfolkVirginia23502-
Investigative Site US308SpokaneWashington99202-

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